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January 14, 2026

US Heart Health Progress Stalls

Kathryn Wighton
January 14, 2026
3 min

A recent report on cardiovascular statistics in the US indicates that nearly 50% of adults meet the criteria for hypertension, marking a significant increase in prevalence based on current guidelines. While hypertension, diabetes, obesity, and dyslipidemia are widespread, treatment and control have seen minimal improvement over the past 15 years. The report highlights persistent disparities influenced by race, income, geography, and age. Researchers utilized data from extensive national surveys and analyses to frame the current landscape of cardiovascular health and mortality.

Nearly 50% of US adults have hypertension based on new guidelines.
Hypertension prevalence increased significantly from historical thresholds.
Limited improvements in treatment and control for hypertension, diabetes, and obesity in the past 15 years.
Disparities exist by race, income, and geography.
High rates of diabetes and obesity impact cardiovascular health.
Majority of adults with chronic conditions are not achieving guideline-recommended goals.

January 14, 2026

Facial AI Shows Promise for BP Screening

Mouj Hijazi
January 14, 2026
3 min

Deep learning analysis of facial images reveals a promising non-invasive method for hypertension screening, achieving 83% accuracy. Conducted by Dr. Jing Wang at Beijing University of Chinese Medicine, the study examined 375 hypertensive patients against 131 controls, using facial regions like the zygomatic and cheek, which matched the performance of traditional methods. This scalable approach could enhance screening adherence and address biases inherent in blood pressure measurement. Future research aims to improve generalizability through larger, diverse cohorts.

Deep learning model identified hypertension with 83% accuracy.
Study involved 375 hypertensive patients and 131 controls.
Zygomatic and cheek regions most informative for diagnosis.
Method utilizes standard cameras, enhancing accessibility.
Future research should involve larger, diverse populations.
AUC for the proposed framework was 84%.
Approach complements traditional blood pressure measurements.

January 14, 2026

AI for Stroke: What the Data Show

Kathryn Wighton
January 14, 2026
3 min

A large prospective observational study revealed that the implementation of artificial intelligence (AI) imaging software in hospitals significantly increased the rates of endovascular thrombectomy for acute stroke patients within England's NHS. The study, analyzing data from 107 hospitals between January 2019 and December 2023, showed a doubling of thrombectomy rates from 2% to 5% at evaluation sites following AI implementation. AI support also led to shorter interhospital transfer times, enhancing patient outcomes, particularly at primary stroke centers where neuroradiology expertise is restricted.

AI imaging software increased thrombectomy rates from 2% to 5% at evaluation sites.
Interhospital transfer times reduced by a median of 64 minutes with AI use.
A 69% adoption of AI software occurred at non-evaluation sites during the study.
AI use led to higher rates of intravenous thrombolysis.
No link between AI use and in-hospital mortality was found.
Residual confounding may have affected results.
Long-term outcomes remain unclear due to limited follow-up.

January 14, 2026

RA Patients Share Views on HIIT

Olivia Anderson
January 14, 2026
4 min

A qualitative study in BMJ Open by Gunilla Limbäck, PhD, and colleagues from the University of Gothenburg examined the experiences of 20 patients with rheumatoid arthritis (RA) undergoing supervised high-intensity interval training (HIIT). Interviews conducted 3 to 6 months post-program revealed both motivating factors and barriers to sustaining exercise. While many perceived improvements in physical capacity and mental well-being, some struggled with motivation afterwards. The findings emphasize the need for ongoing support and tailored exercise programs for RA patients.

Study focused on patients with rheumatoid arthritis and HIIT.
Included 20 patients, primarily women.
Patients reported improved physical and mental well-being.
Barriers to exercise included lack of motivation and life demands.
Importance of physiotherapist guidance highlighted.
Patients emphasized ongoing support for sustained exercise.
Study limited to those with low-to-moderate RA activity.
Professional guidance and social support critical to exercise adherence.

January 14, 2026

Vaccine Guidance Splits: Now What?

Kerri Miller
January 14, 2026
7 min

Legal and policy analysis published in JAMA indicates that clinicians administering vaccines no longer recommended by the CDC face minimal legal risk and likely won't experience immediate disruptions to insurance reimbursements. Recent changes by the Advisory Committee on Immunization Practices (ACIP) have removed several longstanding recommendations, raising concerns among medical societies. Despite the evolving federal vaccination guidelines, experts urge practitioners to continue following established medical protocols, emphasizing their confidence amid the shifting landscape.

Clinicians face minimal legal risk when administering removed vaccines.
The CDC's new recommendations have been questioned by over 45 medical societies.
Insurance coverage likely remains stable through
Federal programs are complex due to potential non-linkage with ACIP changes.
The National Vaccine Injury Compensation Program extends liability protection to vaccine administrators.
Pharmacist vaccination practices may vary by state law.
Patient counseling may need to address vaccine recommendation changes.

January 14, 2026

When Does Quadriceps ACL Graft Mature?

Kathryn Wighton
January 14, 2026
3 min

A recent study published in the Orthopaedic Journal of Sports Medicine evaluated the signal intensity (SI) of quadriceps tendon autografts post-anterior cruciate ligament (ACL) reconstruction in 19 young amateur athletes. The study found significantly elevated SI at 3 and 6 months after surgery, which normalized by 12 months. This suggests that while early changes in graft healing are significant, they approach native ligament values with time. Despite important findings, the study limitations included a small, predominantly female cohort and absence of histology validation.

Study on quadriceps tendon autografts for ACL reconstruction.
19 young athletes aged 13-19 participated in the study.
Signal intensity elevated at 3 and 6 months, normalizing by 12 months.
Significant findings in proximal graft regions.
Limitations: small cohort, lack of histologic validation.

January 14, 2026

AD Pain, Sleep Scales Validated in Phase 3 Trials

Jess Allerton
January 14, 2026
3 min

A psychometric analysis published in Dermatology and Therapy reveals that 3-point and 4-point reductions on the Skin Pain Numeric Rating Scale (SP-NRS) and Sleep Disturbance Numeric Rating Scale (SD-NRS) indicate clinically significant improvement in patients with moderate-to-severe atopic dermatitis. The study analyzed data from three phase 3 trials of rocatinlimab, emphasizing how skin pain and sleep disturbances are crucial patient-reported outcomes beyond itch severity, and aligning with patients' perceptions of treatment benefits.

3-point and 4-point reductions on SP-NRS and SD-NRS are clinically meaningful.
The study analyzed data from three phase 3 trials of rocatinlimab.
Skin pain and sleep disturbance are important outcomes in atopic dermatitis.
Intraclass correlation coefficients of at least
80 indicate high test-retest reliability.
Patient experiences captured by SP-NRS and SD-NRS may differ from clinician assessments.

January 14, 2026

Work Hours Not Tied to Resident Burnout

Kerri Miller
January 14, 2026
7 min

Longer work hours in resident physicians are linked to increased stress and perceived clinical competency, but not burnout, according to a study involving 540 residents in high-burnout specialties. The findings challenge the effectiveness of 2003 duty-hour restrictions in mitigating burnout. Stress levels rose significantly with work hours, while competency ratings improved with longer hours. This suggests that more comprehensive solutions addressing work-life balance and organizational culture are needed to tackle medical resident burnout effectively.

Longer work hours linked to increased stress but not burnout.
Average hours worked by residents was 65 per week.
Study involved 540 residents across various specialties.
Stress associated positively with work hours; competency ratings improved with longer hours.
Findings challenge current duty-hour restrictions aiming to reduce burnout.
Suggested need for more comprehensive interventions addressing organizational culture and work-life balance.

January 14, 2026

Psoriasis Biologics Face Off in Drug Survival Study

Julie Greenbaum
January 14, 2026
2 min

A recent cohort study analyzed biologic therapy for psoriasis among patients in Denmark, evaluating drug survival rates between bionaive and bioexperienced patients. Ustekinumab exhibited the highest drug survival among bionaive patients, with a 5-year discontinuation rate of 37%, while bimekizumab, guselkumab, and risankizumab had better 2-year rates among bioexperienced patients. Data from the DERMBIO registry from 2007 to 2025 included 4,438 patients, emphasizing the importance of biologic selection in clinical practice.

Ustekinumab has the highest drug survival for bionaive patients.
5-year discontinuation rate for ustekinumab is 37%.
Bimekizumab, guselkumab, and risankizumab show better rates for bioexperienced patients.
Analysis based on DERMBIO registry data covering 4,438 patients.
23% of bionaive patients have comorbid psoriatic arthritis.
Drug survival varies significantly based on previous treatment experience.
Study led by Christopher Willy Schwarz, MD, PhD.

The Ophthalmologist

January 14, 2026

Why I Built a Beauty Brand as an Ophthalmologist

Jacqueline Beltz
January 14, 2026
5 min

Ophthalmologists often advise patients with dry or sensitive eyes to avoid cosmetics, which can seem dismissive of individuals' self-expression and confidence. This disconnect inspired the creation of OKKIYO, a beauty brand targeting sensitive eyes, founded by an ophthalmologist who understands the need for ocular care that respects personal identity. By collaborating with cosmetic chemists, various products were developed to be both effective and eye-safe, promoting a balance between medical advice and patient empathy while also supporting accessibility initiatives in eye care.

Ophthalmologists typically advise against cosmetics for sensitive eyes.
OKKIYO was created to provide eye-safe cosmetics.
Products are tested for irritation and effectiveness.
Every sale supports The Fred Hollows Foundation.
Collaboration with cosmetic chemists focuses on sensitive eyes.
The brand aims to balance medical guidance with personal identity.
Empowering patients involves understanding their confidence and self-expression.

The Ophthalmologist

January 14, 2026

Asymptomatic Meibomian Gland Characteristics

January 14, 2026
3 min

Meibomian gland dysfunction (MGD) may progress without noticeable symptoms, as shown in a study from Mahidol University. Evaluating 60 asymptomatic adults aged 31-60, researchers found high rates of meibomian gland abnormalities; 71% showed upper eyelid gland dropout. Despite normal tear function, significant lid margin abnormalities like telangiectasia (82%) and gland plugging (84%) were present. These findings suggest a need for proactive screening to detect early stages of MGD and potentially prevent future dry eye complications.

MGD can progress asymptomatically.
71% of participants showed gland dropout.
High rates of lid margin abnormalities were observed.
Conserved tear function despite gland changes.
Proactive screening for middle-aged adults is recommended.
Absence of symptoms doesn't equal absence of disease.
Early intervention may delay dry eye progression.

The Pathologist

January 14, 2026

What Will Redefine Pathology in 2026?

Jessica Allerton
January 14, 2026
7 min

In 2026, advancements in pathology and laboratory medicine promise to reshape the field. Key predictions include the rise of creative AI in R&D, enhanced long-read sequencing for genetic disorders like Huntington's disease, and increased investment in population-specific genomics. The integration of AI for disease target identification and biological modeling will streamline research processes. Digital twins are expected to gain traction in clinical trials, supported by evolving regulatory frameworks. Unified AI in R&D will replace siloed systems, ultimately improving diagnostic accuracy and efficiency.

2026 to see rise in AI in R&D.
Long-read sequencing vital for genetic conditions.
Digital twins move into routine use in clinical trials.
Unified AI expected to enhance research capabilities.
Cultural shift towards inclusive genomics in various nations.

The Analytical Scientist

January 14, 2026

Mass Spec Roundup: Proteoforms, PFAS, and Volatilomics…

January 14, 2026
4 min

Recent studies have unveiled crucial insights into pancreatic cancer's interaction with its microenvironment and potential risks from hazardous substances in firefighting gear. The first study provided a comprehensive analysis of protein conformational changes and phosphorylation in pancreatic ductal adenocarcinoma, identifying key metabolic enzymes linked to drug resistance. Meanwhile, research uncovered alarming contamination with per- and polyfluoroalkyl substances (PFAS) on firefighter gear, underscoring the health risks they pose. Additionally, advancements in using high-resolution gas chromatography have mapped diet-related changes in gut metabolism, enhancing understanding of microbial fermentation and its implications for health.

Study reveals protein changes in pancreatic cancer cell communication.
Identification of metabolic enzymes linked to drug resistance.
PFAS contamination found on all firefighter protective gear.
Non-destructive wipe test detects harmful substances effectively.
Gas chromatography method maps diet-related gut changes.
Digestive health linked to diet and probiotic use.
Research opens pathways for targeted interventions in pancreatic cancer.

The Medicine Maker

January 14, 2026

Why Europe’s CDMO Sector Must Learn to Dance with Disruption

Joe Renny
January 14, 2026
5 min

The European CDMO sector stands at a pivotal moment defined by disruption from inflation, geopolitical changes, and health crises. These challenges present opportunities for growth through antifragility, a concept advocating that organizations can thrive on adversity. By stepping beyond the subcontractor role, CDMOs can secure their importance in the biopharma ecosystem. They must exploit their strengths in high-value production and regulatory credibility to thrive amidst disruptions like Brexit and the Biosecure Act, framing these challenges as pathways to a resilient future.

Antifragility allows organizations to thrive on adversity.
CDMOs can redefine their roles in biopharma.
The Biosecure Act affects pharmaceutical trade.
Emphasis on modular and digital production is vital.
ESG compliance offers competitive advantages in Europe.
Disruption should be seen as a growth opportunity for CDMOs.
Europe is not declining; it is evolving industrially.
Crisis can turn into opportunity when strategically navigated.

The Medicine Maker

January 14, 2026

Does the Role of CDMO Need to Evolve?

Stephanie Vine
January 14, 2026
9 min

Contract Development and Manufacturing Organizations (CDMOs) are pivotal in aiding pharmaceutical innovation, especially as geopolitical dynamics and complex drug molecules challenge traditional operational models. Mat Minardi from Sterling Pharma Solutions emphasizes the need for CDMOs to rethink their talent deployment and establish strategic long-term partnerships with big pharma. As drug development accelerates, organizations must adapt to provide efficient, cost-effective solutions while navigating pressures on funding and market readiness, ensuring patient-centric outcomes remain paramount.

CDMOs help to drive pharmaceutical innovation.
Outsourcing models are challenged by geopolitical volatility.
Evolving partnerships with big pharma are becoming crucial.
The Extended Bench model allows flexible access to scientific expertise.
Talent competition is increasing due to specialized drug development needs.

The Pathologist

January 14, 2026

Is Point-of-Care Hepatitis C Virus Testing Too Expensive?

January 14, 2026
2 min

An analysis conducted by the University of Washington revealed that broad implementation of point-of-care RNA testing for hepatitis C virus (HCV) could escalate hospital laboratory costs by up to 260%. Evaluating eight years of data from over 325,000 tests in a Seattle medical system, the study highlighted that transitioning to these rapid tests might incur an additional $2.9 million annually in laboratory costs, primarily impacting emergency departments. While faster testing methodologies can enable immediate treatment, the financial implications raise significant concerns about resource allocation within healthcare systems.

Point-of-care RNA testing could increase lab costs by 260% for HCV.
HCV screening could add $
9 million annually in costs.
33% of HCV diagnoses are from county hospital emergency departments.
Traditional testing has a median turnaround time of 84 hours.
HCV antigen testing is a cost-effective alternative, adding only $11,494 annually.
Emergency department testing for HCV increased 682% from 2017 to
Current Medicare reimbursement rates underestimate actual costs.

January 14, 2026

Medical Oddities: A Vaccine With a Foam Head?

Teraya Smith
January 14, 2026
5 min

Chuck Buck, a virologist at the US National Cancer Institute, is pioneering a novel oral vaccine against BK polyomavirus using genetically engineered yeast as a carrier. This virus can lead to severe health issues in immunosuppressed patients. Animal studies showed promising antibody responses with injectable forms. Buck's self-experimentation with this yeast-infused beer resulted in increased antibodies, igniting discussions on vaccine innovation. Concurrently, a study found that TV depictions of CPR often misrepresent life-saving techniques. Additionally, a clinical trial indicated that introducing yoga alongside standard treatment could benefit patients undergoing opioid withdrawal. Lastly, a large UK study revealed tea's inability to mitigate the obesity risk associated with high meat consumption.

Vaccine against BK polyomavirus uses genetically engineered yeast.
Buck's self-experiment resulted in increased antibodies.
TV depictions of CPR frequently misrepresent techniques.
Yoga may improve outcomes in opioid withdrawal treatment.
Higher tea intake is linked to lower obesity risk, but does not offset high meat intake.

KFF Health News

January 14, 2026

Rural Care Gets Billions — Now What?

Sarah Jane Tribble
Arielle Zionts
Maia Rosenfeld
January 14, 2026
8 min

The federal government has initiated a Rural Health Transformation Program, distributing at least $147 million to each state to address healthcare access issues for rural Americans. Announced by President Trump's administration, funding varies significantly among states; for instance, Texas will receive $281 million while Rhode Island gets $6,300 per rural resident. States must demonstrate effective use of these funds in eight months, with assessments impacting future allocations. The program is part of a broader effort to mitigate the expected repercussions of Medicaid spending cuts on rural communities.

The Rural Health Transformation Program allocates funds to improve healthcare access in rural areas.
Each state must submit revised budgets within eight months to access funds.
Allocations vary significantly based on a technical scoring system.
Texas received the highest allocation, while Rhode Island received the lowest per rural resident.
States must align funding proposals with federal health policy initiatives to maximize their scores and future funding potential.

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