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MDSpire is an innovative platform aiming to create a smarter, faster, and more connected medical community.

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The Ophthalmologist

November 28, 2025

Global Myopia Awards

November 28, 2025
2 min

Jennifer Lambert, Vice President of Myopia Management & Cornea Care at CooperVision, received two prestigious Stevie® Awards for her leadership in childhood myopia management during a ceremony in New York City on November 10, 2025. She was recognized as the Silver Stevie® Female Executive of the Year in the consumer products sector and as the Bronze Stevie® Woman of the Year in Healthcare. Lambert has led the global adoption of evidence-based myopia care, significantly contributing to the launch of MiSight® 1 day lenses, the first FDA-approved contact lens to slow myopia progression in children.

Jennifer Lambert recognized at 2025 Stevie® Awards.
Awarded Silver for Female Executive and Bronze for Woman of the Year in Healthcare.
Led the expansion of MiSight® 1 day contact lenses to over 40 countries.
MiSight® is FDA-approved for slowing myopia progression in children aged 8-
Partnered with World Council of Optometry to enhance myopia management practices.
Focus on evidence-based clinical care for children's vision health.
Lambert's leadership has global impact on myopia management.

The Ophthalmologist

November 28, 2025

Expanding ERG in Diabetic Eye Care

Raj K. Maturi
November 28, 2025
6 min

Diabetic retinopathy is increasingly prevalent, affecting an estimated 9.6 million individuals in the US, with nearly 2 million at the vision-threatening stage. As the need for effective risk management rises, electroretinography (ERG) emerges as a valuable tool to identify functional retinal changes before structural alterations. Current handheld ERG devices facilitate efficient, non-invasive testing. Recent studies highlight ERG's predictive capabilities, prompting a shift in diabetic eye care towards proactive intervention strategies focused on preserving vision.

- Diabetic retinopathy affected
6 million in the US in
- Nearly 2 million are in vision-threatening stages. - Handheld ERG devices are efficient and non-invasive. - ERG detects functional changes before structural ones. - RETeval DR Score predicts progression to complications. - ERG is included in AAO guidelines for diabetic retinopathy. - Early intervention can preserve vision outcomes.

The Medicine Maker

November 28, 2025

The Shift to Agile, Modular Manufacturing

November 28, 2025
1 min

At CPHI Frankfurt 2025, Cytiva showcased its KUBio box trailer featuring the FlexFactory manufacturing solution, reflecting the industry's transition to personalized therapies like mRNA and gene therapies. Joe Wakowiecki, Cytiva's Enterprise Solutions Director, emphasizes the trend towards smaller, agile manufacturing environments that prioritize flexibility. Cytiva provides extensive biomanufacturing support, covering all aspects from facility design to operator training, enabling clients to concentrate on scientific endeavors while Cytiva handles infrastructure complexities.

Cytiva's FlexFactory showcased at CPHI Frankfurt
Focus on agile and modular biomanufacturing.
Shift towards personalized therapies including mRNA.
Comprehensive lifecycle support from facility design to training.
Aims to reduce complexity in biomanufacturing processes.

The Pathologist

November 28, 2025

Whole-Genome Sequencing Assay Detects HPV

Jim Gallagher
November 28, 2025
4 min

HPV-DeepSeek, a next-generation liquid biopsy test, shows exceptional sensitivity (98.7%) and specificity (99.1%) for detecting HPV-related circulating tumor DNA in over 400 patients. Presented by Dr. Adam S. Fisch at the AMP 2025 meeting, the assay targets 43 HPV genotypes and has potential applications in early diagnosis, treatment monitoring, and assessment of residual disease across various cancer types, including oropharyngeal and cervical cancers, while providing insights into specific mutations and viral integration patterns.

HPV-DeepSeek assay shows
7% sensitivity,
1% specificity.
Targets 43 HPV genotypes, crucial for early cancer detection.
Study involved 224 patients with HPV-associated squamous cell carcinoma.
High median genome coverage near 100% in true-positive cases.
Reports PIK3CA mutations and viral integration patterns.
Observations align with established cancer-site-specific tendencies.
Potential applications in treatment monitoring and assessing residual disease.

The Pathologist

November 28, 2025

Building Programs and People

Helen Bristow
November 28, 2025
9 min

Pathology has evolved significantly over the years, driven by scientific advancements and a commitment to better clinical care. The interviewee, a department head at the University of Pennsylvania, reflects on his journey from early interest in pathology to leadership roles, emphasizing the importance of integrating molecular diagnostics and AI into the field. He sees potential in antibody-drug conjugates and envisions a future where pathologists can leverage technology to enhance cancer treatment. His leadership philosophy centers on cultivating talent and focusing on the impact of educational efforts in pathology.

Pathology combines biological sciences and clinical research.
The field has undergone significant revolutions: immunohistochemistry, molecular diagnostics, and AI integration.
The UPenn department excels in NIH funding and research advancements.
AI and machine learning will shape pathology's future practices.
Antibody-drug conjugates offer new therapeutic pathways.
Leadership in pathology focuses on developing talent and integrity.
Engaging with global scientific communities enhances research visibility.

The Medicine Maker

November 28, 2025

Five Tips for Optimizing Genomics Workflows

Paul Lomax
November 28, 2025
4 min

Advancements in genomics present both opportunities and challenges for laboratories focusing on liquid handling processes. Automation enhances reproducibility, miniaturization improves efficiency, and seamless integration of workflows enhances overall productivity. A balance between throughput and flexibility is essential for adapting to evolving research needs, while sustainability considerations can significantly reduce environmental impact. Continuous refinement in these areas promotes more reliable and cost-effective genomics workflows and drives innovation in the field.

Automation improves reproducibility in liquid handling.
Miniaturization reduces costs and increases throughput.
Integrated workflows enhance efficiency and consistency.
Flexibility in design supports various research priorities.
Sustainability in lab processes can reduce environmental impact.
Continuous refinement in workflows is essential for innovation.
Collaboration across disciplines improves overall lab productivity.

The Ophthalmologist

November 27, 2025

Time Machine: Chapter 34

Christopher T. Leffler
B. Frits Hogewind
Stephen G. Schwartz
Andrzej Grzybowski
November 27, 2025
2 min

The evolution of ophthalmology in cataract surgery began with Jacques Daviel's documented cataract extraction on September 18, 1750, in Cologne. This transition from traditional couching to extraction was influenced by three Paris-based surgeons in July 1750, notably Jean Baseilhac, Natale Pallucci, and Daviel himself. Baseilhac's technique was criticized, while Pallucci made strides with lens fragment removal. However, it was Daviel who ultimately gained recognition for documenting the method and sharing his insights, marking a revolution in ocular surgery techniques.

Cataract surgery transitioned from couching to extraction in
Jacques Daviel documented the first planned cataract extraction.
Jean Baseilhac began cataract extractions in July 1750 but had poor techniques.
Natale Pallucci also experimented with cataract extraction techniques.
Daviel's animal experiments began on July 7, 1750, in Leuven.
Frère Côme was innovative in lithotomy but not in ophthalmology.
The debate over the first cataract extraction continues among these surgeons.

The Analytical Scientist

November 27, 2025

New Workflow for Precise Bile Acid Profiling and Multi-Omics Discovery

November 27, 2025
2 min

A team of scientists has developed a next-generation LC-MS/MS workflow using the ZenoTOF 8600 system to advance bile acid analysis. This innovative approach addresses challenges related to the complexity of bile acids, offering high specificity and speed in profiling, thereby aiding diagnostics and therapeutics. Utilizing electron-activated dissociation (EAD), the new technique distinguishes isomeric bile acids and reduces chemical noise. This breakthrough facilitates rapid analysis, which could significantly impact future research in metabolomics and gut health.

Developed a next-gen LC-MS/MS workflow for bile acid analysis.
Overcomes analytical challenges associated with bile complexity.
Utilizes ZenoTOF 8600 system for high specificity and speed.
Employs electron-activated dissociation for better isomer differentiation.
Takes under 10 minutes for result delivery.
Promises to advance research in metabolomics and gut health.
Aims to enable early diagnostics and personalized therapies.

The Medicine Maker

November 27, 2025

Discussing the Big Ideas in Medicine Manufacturing

November 27, 2025
8 min

During the World Medical Innovation Forum 2025, leaders at Mass General Brigham discussed 'Big Ideas in Medicine,' emphasizing advances in drug discovery and manufacturing. Experts highlighted the importance of scalable genetic medicine, AI-driven automation in pharma manufacturing, and sustainable practices. Innovations such as digital twins and data-driven frameworks are set to improve predictability and efficiency. The future is focused on overcoming manufacturing challenges to ensure accessibility of advanced therapies to patients worldwide.

AI and automation are key for predictive, scalable manufacturing.
Digital twins help in simulating production scenarios.
The industry seeks to revolutionize CGT manufacturing for better patient access.
Sustainability is essential for future growth in pharma.
A standardized approach will enhance technology transfer and consistency.
The shift from manual to automated processes is critical.
Close-to-patient manufacturing is a priority for CGT products.
Innovation in manufacturing must align with advances in therapy development.

The Medicine Maker

November 27, 2025

Understanding the Benefits of Gelatin and Collagen

November 27, 2025
1 min

Gelatin and collagen serve vital functions in biomedical applications, impacting fields such as tissue engineering and drug delivery. In an interview with Samy Jandall, GVP of Global Business Management at GELITA Group, the significance of endotoxin-controlled excipients is also highlighted, emphasizing their role in ensuring safety and efficacy in pharmaceutical products. The discussion underlines the intersection of biomedicine and manufacturing standards, revealing how critical quality control is for patient health.

Gelatin and collagen are crucial in biomedical applications.
They impact tissue engineering and drug delivery.
Endotoxin-controlled excipients are vital for safety.
Samy Jandall is the GVP at GELITA Group.
Quality control is essential for patient health.

The Medicine Maker

November 27, 2025

The Evolution of Syringe Systems

November 27, 2025
1 min

Andy Polywacz, President of Integrated Systems at West Pharmaceutical Services, discusses the advancements in drug delivery that are shaping the pharmaceutical industry's future. He highlights the launch of a new prefillable syringe system designed to improve efficiency and ease of use in medication administration. This innovation aims to enhance patient safety and streamline the drug delivery process, reflecting a commitment to meet evolving healthcare needs.

Andy Polywacz is the President of Integrated Systems at West Pharmaceutical Services.
New prefillable syringe system launched.
Designed to improve efficiency in drug delivery.
Aims to enhance patient safety.
Represents advancements in pharmaceutical technology.

The Analytical Scientist

November 27, 2025

Tracking Residual Disease in Myeloma With Flow Cytometry

November 27, 2025
2 min

A recent study highlights the role of flow cytometry in diagnosing and monitoring plasma cell neoplasms, particularly multiple myeloma. Over 95% of these neoplasms demonstrate a loss of CD19, a significant immunophenotypic abnormality. Normal plasma cells display distinct markers such as bright CD38 and positivity for CD19 and CD138, while neoplastic cells show altered markers, helping differentiate them effectively. The study emphasizes the importance of measurable residual disease (MRD) testing and the influence of markers on prognostic outcomes, especially post-therapy.

Over 95% of plasma cell neoplasms exhibit loss of CD
Flow cytometry differentiates normal from neoplastic plasma cells effectively.
Normal plasma cells show bright CD38, positivity for CD19 and CD
Anti-CD38 agents like daratumumab can affect detection.
MRD testing is crucial for monitoring post-therapy outcomes.
Persisting MRD correlates with inferior progression-free survival.
Panel design and accurate gating are key in flow cytometry.

The Analytical Scientist

November 27, 2025

Bioelectronic Patch Intervenes to Manage Blood Pressure

James Strachan
November 27, 2025
4 min

Researchers have developed a closed-loop bioelectronic patch aimed at improving hypertension management by delivering therapy in real-time. This system combines advanced microneedle technology and electrochemical methods to release nitric oxide when blood pressure spikes, offering a potential alternative to traditional oral medications, especially for patients with unstable blood pressure. Interdisciplinary collaboration played a crucial role in optimizing the technology, which may extend beyond hypertension to treat conditions such as arrhythmia and chronic wounds. Wansong Chen from Central South University led the research published in Science Advances.

Closed-loop patch delivers nitric oxide for blood pressure spikes.
Combines microneedle technology with electrochemical methods.
Targeted towards patients with unstable blood pressure.
Interdisciplinary collaboration was key in development.
Future exploration for other therapeutic targets is planned.
Testing in pig models shows potential for human trials.
Possible applications extend beyond hypertension to other conditions.

The Pathologist

November 27, 2025

Inside the Race to Detect Neurodegenerative Disease Early

Jessica Allerton
November 27, 2025
6 min

Advancements in neurodegenerative disease diagnostics play a crucial role in enhancing patient outcomes. Amprion, led by CEO Russ Lebovitz, has shifted its focus from Creutzfeldt-Jakob disease to developing diagnostics for prevalent conditions like Parkinson's and Huntington's disease. Their SAAmplify-αSyn test has shown remarkable accuracy, detecting biomarkers years before clinical diagnosis. This innovation could also pave the way for broader applications in Huntington’s diagnostics, employing protein misfolding assays to improve mutation detection and treatment precision.

Early detection of neurodegenerative diseases is vital for patient outcomes.
Amprion focuses on diagnostics for Alzheimer's, Parkinson's, and Huntington’s diseases.
SAAmplify-αSyn assay shows exceptional accuracy in detecting biomarkers.
The test can identify active disease years before clinical diagnosis.
Precision medicine is emerging as a diagnostic approach.
Innovations in AI and biomarker science are shaping future diagnostics.
80 million people worldwide live with neurodegenerative diseases.

The Pathologist

November 27, 2025

Researchers Unveil Multiplex PCR for Endemic Fungi

November 27, 2025
3 min

Researchers at Indiana University have developed a novel multiplex real-time PCR assay that significantly speeds up the identification of Histoplasma, Blastomyces, and Coccidioides fungal infections, which are endemic in the US. Led by Dr. Kenneth Gavina, the assay can detect these pathogens directly from clinical specimens in a single run, bypassing traditional culture methods that are time-consuming. The technology, using a simplified lysis method, shows promising results, potentially leading to improved patient outcomes through faster diagnosis and treatment initiation.

New multiplex PCR assay developed for fungal infections.
Targets Histoplasma, Blastomyces, and Coccidioides.
Bypasses slow culture methods.
Led by Dr. Kenneth Gavina at Indiana University.
Shows 100% agreement with standard testing.
Potentially improves diagnostic time for immunocompromised patients.
Utilizes simplified lysis method for pathogen inactivation.

The Ophthalmologist

November 27, 2025

Reviewing the Dry Eye Landscape

November 27, 2025
4 min

The systematic review by Clara C. Chan and colleagues evaluates over 100 publications to analyze current topical pharmacologic treatments for dry eye disease (DED). This review highlights a shift from lubrication to mechanism-targeted therapies over the past decade, noting the efficacy of anti-inflammatory agents and new formulations such as cyclopsorine and lifitegrast. While objective improvements in DED symptoms like corneal staining are common, patient-reported symptom relief remains inconsistent, underscoring the need for tailored treatment strategies and multidisciplinary approaches in DED management.

Systems review evaluates over 100 publications on dry eye disease treatments.
Shift from lubrication to mechanism-targeted therapies noted in past decade.
Anti-inflammatory agents demonstrate strong efficacy.
Disconnect between objective improvement and patient-reported symptoms emphasized.
Identification of DED mechanism helps in therapy selection.

November 26, 2025

FDA Grants Accelerated Approval of Voyxact

Kathryn Wighton
November 26, 2025
2 min

The FDA has granted accelerated approval for Voyxact (sibeprenlimab-szsi) injection aimed at reducing proteinuria in adults with primary immunoglobulin A nephropathy, a condition resulting from abnormal IgA antibody deposits in the kidneys. This disease is typically diagnosed in young adults and can lead to kidney failure. Results from a randomized trial showed a 50% reduction in protein levels in patients using Voyxact at 9 months. Safety protocols emphasize monitoring for infections and avoiding live vaccines prior to and during treatment. Continued approval will depend on further evidence from the ongoing VISIONARY trial regarding its long-term effects on kidney function.

FDA approved Voyxact for IgA nephropathy.
Significant reduction in proteinuria observed in trial.
Recommended dose: 400 mg subcutaneously every 4 weeks.
Safety monitoring required for active infections.
Live vaccines should be avoided.
Common adverse effects include infections and injection site reactions.
Long-term kidney function effects still under evaluation in VISIONARY trial.

November 26, 2025

Chronic Cough Linked to GLP-1 Agonists

Kerri Miller
November 26, 2025
4 min

A recent study examining data from over 2 million patients revealed that individuals with type 2 diabetes taking glucagon-like peptide-1 receptor agonists (GLP-1 RAs) face a heightened risk of developing chronic cough compared to those on other diabetes medications. Led by Dr. Tyler J. Gallagher, this retrospective analysis used records from 70 U.S. healthcare organizations. Findings emphasized the need for healthcare providers to recognize this potential side effect and manage symptoms accordingly, particularly for those without gastrointestinal symptoms, as chronic cough may indicate gastroesophageal reflux disease.

Study examines over 2 million patients with type 2 diabetes.
Increased chronic cough risk associated with GLP-1 RAs.
Long-acting GLP-1 RAs showed stronger association with cough.
Potential link: activation of the vagal nerve.
GERD may present as chronic cough without typical GI symptoms.
Management should consider reflux treatment for cough.
Acknowledges limitations such as lack of cough severity measures.
No conflicts of interest reported by researchers.

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