Objective: To validate the prognostic value of tumor budding (TB) and tertiary lymphoid structures (TLS) in oral squamous cell carcinoma (OSCC) and establish a
Objective: To synthesize current knowledge on the mechanisms underlying the transformation of oral potentially malignant disorders (OPMDs) to oral squamous cell
Oral potentially malignant disorders (OPMDs) have a significant risk of progression to oral squamous cell carcinoma (OSCC), complicating early detection.
Malignant transformation from OPMDs to OSCC is driven by genetic mutations, epigenetic changes, and chronic inflammation, often preceding visible histological alterations.
The tumor microenvironment, influenced by chronic inflammation and oxidative stress, fosters conditions that promote malignant progression in OPMDs.
Oral submucous fibrosis (OSMF) serves as a high-risk model for studying malignant transformation due to its unique extracellular matrix changes.
Integrating multi-omics data with artificial intelligence can enhance risk assessment and early detection of high-risk lesions in oral cancer.
Objective: To develop consensus-driven recommendations for the evaluation and management of sinonasal masses. Key Findings: Physicians should maintain suspicion
Objective: To systematically evaluate the contributions of dose and product characteristics to vaping-associated transcriptomic alterations in oral epithelial c
Objective: To analyze the differences in antibiotic resistance and biofilm-forming capacity of supragingival bacteria in patients with active dental caries comp
Patients with active dental caries exhibit species-specific differences in antibiotic resistance compared to those with good oral health.
In a study of 319 bacterial isolates, significant differences in susceptibility to ampicillin were found in Veillonella parvula between caries and healthy patients.
Biofilm formation varied, with 79% of isolates from caries patients classified as moderate biofilm producers, while 82% from healthy patients were non-biofilm producers.
Resistant isolates were identified across multiple taxa, including Streptococcus oralis and Fusobacterium nucleatum, with beta-lactamase activity confirmed in some.
The study's findings indicate that associations between caries and antibiotic resistance are species-specific and not universally applicable across all taxa.
Objective: To identify disease-associated immune cell subsets and gene regulatory mechanisms in periodontitis, focusing on the role of N4BP1 in neutrophil and e
Objective: To investigate cytokine-associated inflammatory and fibrotic responses, specifically IL-6, TNF-α, and MMP-2, following treatment with a mucoadhesive
Objective: To introduce and evaluate a tailored 360-degree multisource feedback system in clinical internships for undergraduate dental students. Key Findings:
The study introduced multisource feedback into clinical internships for undergraduate dental students, marking its first application in this context.
A tailored 360-degree evaluation system was developed, involving 77 students, two clinical instructors, and one nursing staff member.
The dental students achieved an average score of 86.78, indicating strong performance in professionalism, clinical competence, and collaboration.
Significant differences were found in collaboration and communication skill ratings among clinical instructors, nursing staff, and peers.
Multisource feedback provides a comprehensive assessment of student competencies and instructor teaching abilities, highlighting areas for improvement.
Objective: To guide the development of novel therapies for oral mucosal barrier-related diseases and provide a scientific basis for the integrated management of
The oral mucosa is a critical immune barrier that protects against pathogens and maintains both local oral health and systemic well-being.
Barrier remodeling involves structural, immunological, ecological, and functional processes that determine the restoration of homeostasis or progression to dysfunction.
Dysfunctional oral mucosa can exacerbate local lesions and worsen systemic diseases through the oral-systemic axis.
Cutting-edge technologies have enhanced understanding of oral barrier remodeling, leading to novel therapeutic strategies for restoration.
Research limitations include a lack of integrated mechanistic studies and standardized protocols, necessitating collaboration between basic research and clinical practice.
Objective: To compare mental health diagnoses and treatment patterns between health care workers and non–health care workers during and after the COVID-19 pande
Objective: To assess periodontal health in pregnant patients with type 1 diabetes mellitus (T1DM) compared to healthy controls. Key Findings: Patients with T1DM
Objective: To characterize the mutational and molecular profiles of oral cavity squamous cell carcinomas (OSCC) without traditional risk factors. Key Findings:
Oral cavity squamous cell carcinomas without known risk factors exhibit distinct mutational and molecular profiles compared to tobacco-associated cancers.
Researchers identified two main subtypes among tumors with no identified risk factors, predominantly represented by SBS1 and SBS1/APOBEC mutational clusters.
The SBS1 cluster accounted for 60% of tumors with no identified risk factors, while the SBS1/APOBEC cluster represented 34% of these tumors.
Younger patients were more frequently found in the SBS1 cluster, whereas older patients were distributed between the SBS1 and SBS1/APOBEC groups.
The study highlights distinct genomic characteristics of no-identified-risk-factor oral cancers, revealing unique biological pathways and immune response mutations.
Objective: To review the evolving shift in peri-implantitis research from traditional mechanical debridement toward host-modulatory and immunopharmacological co
Peri-implantitis is an immunologically complex condition, necessitating a shift from mechanical debridement to host-modulatory therapies.
Emerging therapeutic strategies include targeted anti-cytokine biologics and macrophage-directed approaches, though most are still in preclinical stages.
Advanced drug delivery systems, such as stimuli-responsive hydrogels, may enhance localized treatment for peri-implantitis.
Single-cell RNA sequencing has revealed distinct immune microenvironment characteristics in peri-implantitis compared to healthy tissues.
Future management of peri-implantitis may rely on immunopharmacological strategies, biomarker diagnostics, and artificial intelligence for personalized care.
Objective: To investigate whether periodontitis accelerates CD4+ T-cell senescence and its subsequent impact on systemic diseases, particularly rheumatoid arthr
Objective: To assess the quality and reliability of YouTube videos related to oral hygiene uploaded between February 2020 and February 2023. Key Findings: 76% o
Objective: To critique the Western epistemological foundations of oral health professionalism in Africa and propose an alternative informed by Ubuntu philosophy
The Western model of oral health professionalism in Africa emphasizes clinical detachment, neglecting indigenous knowledge and community perspectives.
Yorùbá communities view oral health as integral to spiritual personhood, linking dental care to broader concepts of dignity and self-care.
Colonial health systems in Africa perpetuate an epistemic hierarchy that marginalizes indigenous knowledge and prioritizes curative over preventive care.
An Ubuntu-informed framework promotes mutual vulnerability and ecological professional identity, fostering accountability to marginalized communities.
Transforming dental education in Africa requires a shift towards relational approaches that integrate community knowledge and prioritize holistic care.
Objective: To develop and validate a standardized radiographic evaluation tool, DENTALE, for assessing late dental adverse effects in survivors of childhood can
Objective: To evaluate the reliability of orthodontic retention information produced by different AI-based programs in terms of accuracy, relevance, and readabi