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MDSpire News

October 9, 2026

Rhinolith may hide intranasal ectopic tooth

Andrea Surnit
October 9, 2026
3 min

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Objective: The article examines the objective, findings, and clinical context described in Rhinolith may hide intranasal ectopic tooth. Approach: Case: A 45-yea

...more

A 45-year-old man had 6 months of foul-smelling right-sided nasal discharge and intermittent mild epistaxis.
Endoscopy showed a hard, irregular mass on the right nasal cavity floor, partly surrounded by calcified material.
CT demonstrated a tooth-like structure with enamel, dentin, and a central pulp cavity, surrounded by calcifications consistent with a rhinolith.
Endoscopic transnasal removal of the ectopic tooth and rhinolith was uncomplicated, and the patient’s symptoms resolved.
The authors noted that CT characterizes ectopic tooth morphology and location, while endoscopy enables direct visualization and surgical management.

...more

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Baptist Health South Florida

October 9, 2026

Oral Toxicities With Antibody-Drug Conjugates: What Physicians Should Know

October 9, 2026
4 min

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Objective: To describe oral toxicities among patients with advanced cancer treated with TROP2- or HER2-directed antibody-drug conjugates (ADCs). Approach: Study

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2 min

In a retrospective multicenter cohort of 207 patients with advanced cancer treated with TROP2- or HER2-directed ADCs, 22.7% developed at least 1 oral toxicity.
Oral mucositis was more common with TROP2-directed than HER2-directed ADCs (14.8% vs 5.4%), and adjusted odds were approximately 3 times higher with TROP2 therapy.
Dysgeusia and xerostomia were more common with HER2-directed ADCs, although differences between treatment groups were not statistically significant.
Topical corticosteroids did not improve existing mucositis or prevent new lesions, whereas 4 patients treated with oral cryotherapy had symptomatic improvement and fewer new ulcers.
The retrospective design, predominance of patients with breast cancer, and reliance on medical records may limit generalizability and have led to underreporting of oral toxicities.

...more

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Digital Health

October 9, 2026

Developing and Defining the GAPA Digital Infrastructure for Coordinated Oral Health Planning Across Home Care Organizations

Sara Björns
Jessica Persson Kylén
October 9, 2026

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Objective: To develop and specify a cross-organisational digital platform for shared oral health care planning between municipal home care and public dental ser

...more

The GAPA programme aims to integrate oral health care into home care through an interprofessional, person-centred work model.
The study developed a digital platform for shared oral health planning between municipal home care and public dental services in Sweden.
Platform requirements included structured assessments, older adults’ preferences and consent, agreed actions, responsible actors, and follow-up.
The platform was designed to keep unresolved oral health needs visible across organisational boundaries.
This development study specified and refined the platform but did not evaluate implementation, effectiveness, or patient outcomes.

...more

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United States Department Of Health And Human Services

October 8, 2026

HHS Civil Rights Office Resolves HIPAA Privacy Rule Probe Involving Dr. Linda L. Shen and Shen Smiles, P.C.

Office for Civil Rights (OCR)
October 8, 2026

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Objective: The article describes an OCR investigation into alleged delayed access to a patient’s protected health information and the resulting settlement with

...more

1 min

HHS OCR resolved a HIPAA Privacy Rule investigation of Pennsylvania dental provider Linda L. Shen, doing business as Shen Smiles, P.C.
The investigation followed a complaint alleging that Shen Smiles delayed access to an individual’s protected health information despite multiple requests.
OCR found that Shen Smiles lacked required policies and procedures, including those addressing individuals’ access rights, and had not reasonably safeguarded PHI.
Shen Smiles said it could not provide access because a workforce member had stolen the records.
The parties settled on August 11, 2026, before an administrative hearing, and Shen Smiles agreed to pay OCR $140,000.

...more

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Digital Health

October 8, 2026

Strategies for Promoting Teledentistry Adoption in Dental Care: A Realist Review

Krithika Priyadharshini Arunagiri
Paul Allison
Shashank Kannan
Pascaline Kengne Talla
October 8, 2026

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Objective: To investigate how implementation strategies interact with context and mechanisms to shape teledentistry implementation outcomes, including what work

...more

4 min

Teledentistry uses information and communication technologies for services such as screening, triage, consultation, diagnosis, monitoring, referrals, and patient education.
Teledentistry can reduce patient waiting times and expenses, improve satisfaction, and support specialist consultation and collaboration among oral health care providers.
Implementation barriers include limited provider knowledge, patient awareness, training, and reimbursement, as well as digital divides, low digital health literacy, and unclear guidelines and legal fr
The review aims to characterize strategies promoting teledentistry adoption and examine their contexts, mechanisms, and implementation outcomes across dental care settings.
The authors conducted a realist review using Pawson and Tilley’s five-stage framework; its protocol was registered in PROSPERO and published in the International Journal of Qualitative Methods.

...more

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MDSpire News

October 5, 2026

Speech aging may differ across dementia phenotypes

Andrea Surnit
October 5, 2026
4 min

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The study analyzed speech features from 2,928 Spanish-speaking participants, including healthy controls and various dementia phenotypes.
Speech age gaps (SAGs) were calculated, showing that healthy controls had lower gaps compared to dementia patients, particularly those with ldFTD and nldFTD.
Larger SAGs were linked to poorer performance in clinical and cognitive measures, with stronger associations observed in linguistic tasks.
SAGs correlated with neurodegeneration markers, including plasma p-Tau217, and showed positive associations with brain-age gaps.
The study's limitations included its cross-sectional design and the restriction to Latin American populations, affecting generalizability.

...more

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MDSpire News

October 5, 2026

Toothpastes may transiently alter salivary calcium

Andrea Surnit
October 5, 2026
4 min

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Objective: To investigate the short-term effects of different fluoride toothpaste formulations on total salivary calcium concentration following brushing. Appro

...more

2 min

Different fluoride toothpaste formulations produced varying short-term changes in total salivary calcium after brushing.
The study involved 48 healthy participants, with a mean age of 22.55 years, using three types of sodium fluoride toothpaste.
Immediately after brushing, Dentalux and Sensodyne showed higher salivary calcium concentrations compared to Parodontax.
By 60 minutes post-brushing, no statistically significant differences in salivary calcium remained among the toothpaste formulations.
The study's findings indicate that the observed effects on salivary calcium were transient and do not establish long-term oral health impacts.

...more

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Infection

October 3, 2026

Frequency and Clinical Significance of Dento-Alveolar Infections in Periprosthetic Joint Infections: A Retrospective Analysis of 213 Cases

Christina Pempe
Gerhard Schmalz
Dirk Ziebolz
Andreas Roth
October 3, 2026

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Objective: To establish the prevalence of dento-alveolar foci among patients with hip or knee periprosthetic joint infections (PJI) and compare clinical outcome

...more

Periprosthetic joint infection (PJI) occurs in 0.5%-2% of primary arthroplasties and 15%-36% of revision cases.
Oral and dental conditions may serve as extra-articular infection sources, potentially contributing to up to 10% of late PJIs.
The clinical significance of dental foci in PJI is uncertain, with mixed opinions on the necessity of routine dental assessments.
This study aimed to determine the prevalence of dento-alveolar foci in PJI patients and compare clinical outcomes based on dental status.
The analysis included 213 PJI cases, with a mean patient age of 71.9 years, predominantly involving hip infections.

...more

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Journal Of Medical Internet Research

October 2, 2026

Evaluating Periodontitis Risk and Prevention Strategies: A Comparative Analysis of Multimodal Large Language Models and Periodontist Assessments

Laura Swinckels
Katharina Alves Rabelo
Eduardo L Delamare
Bruno G Loos
Pierre Lahoud
Harmen Bijwaard
Ander de Keijzer
Jinman Kim
Josef Bruers
October 2, 2026

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Periodontitis is an inflammatory disorder that affects periodontal tissues and may have systemic health consequences.
The disease is largely preventable but has a high prevalence in the oral cavity due to its multifactorial etiology.
Dental professionals assess early clinical signs and encourage healthy behaviors while considering nonmodifiable risk factors.
Information pertinent to dental care should be documented in electronic health records to support personalized treatment.
AI has been explored as a tool for supporting clinical decision-making in dentistry, particularly for preventive measures.

...more

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Journal Of Medical Internet Research

September 29, 2026

Correction: Factors Influencing and Hindering Global Digital Oral Health Initiatives: A Mixed Methods Analysis

Elham Emami
Pascaline Kengne Talla
Camille Inquimbert
Nicolas Giraudeau
September 29, 2026

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Objective: To report corrections made to the results section of a previous article regarding facilitators and barriers in global digital oral health. Approach:

...more

The article titled 'Facilitators and Barriers in Worldwide Digital Oral Health' underwent corrections in the Results section.
Revisions were made to a sentence under the Characteristics of the Study Participants subsection.
Changes were also implemented in the Barriers subsection of the Study Findings.
The corrected sentences in the Barriers subsection were specified but not detailed in the context.
The corrected article was resubmitted to PubMed, PubMed Central, and other full-text repositories.

...more

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MDSpire News

September 28, 2026

VA/DoD guideline broadens tobacco treatment

Andrea Surnit
September 28, 2026
5 min

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Objective: To provide updated clinical practice guidelines for tobacco and nicotine dependence treatment in military service members and veterans. Approach: Gui

...more

2 min

The VA and DoD have released a guideline expanding tobacco treatment recommendations for military service members and veterans.
The guideline includes 32 recommendations across 10 areas, emphasizing complete abstinence from tobacco or nicotine.
Varenicline is strongly recommended for combustible tobacco cessation, outperforming bupropion and single-agent NRT.
The guideline weakly recommends pharmacotherapy for patients not ready to quit and for those with stable mental health conditions.
Evidence quality varied across recommendations, with limited data on newer nicotine products and a need for further research.

...more

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MDSpire News

September 24, 2026

Medical Oddities: Your physiology may know when you're alone

Teraya Smith
September 24, 2026
5 min

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Objective: To explore how a close partner's presence affects homeostatic responses in adults and infants. Approach: Study Design: Three experiments involving 18

...more

2 min

A study from Hebrew University found that partner presence reduced glycemic response by 14.6% and thermoregulatory responses to cold by 6.8% in adults.
Olfactory reference syndrome (ORS) causes patients to believe they emit offensive odors, leading to anxiety and impaired functioning, as shown in a case report.
Fluorescence-aided caries excavation (FACE) helps dentists identify infected dentin, preserving more healthy tissue compared to conventional methods.
Research on black tea polysaccharide BTPS3 indicates it may enhance gut health by increasing short-chain fatty acid production during fermentation.
The findings across various studies highlight the complex interactions between physiology, psychology, and microbiology in health.

...more

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United States Department Of Health And Human Services

September 23, 2026

HHS Allocates $51 Million to Enhance Dental Services for Children with Neurodevelopmental Disorders

Assistant Secretary for Public Affairs (ASPA)
September 23, 2026

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Objective: To support expanded dental-care access for children with neurodevelopmental disorders through funding to health centers. Approach: Funding Allocation

...more

HHS allocated $51 million to 28 health centers to enhance dental services for children with neurodevelopmental disorders.
The funding aims to improve access to preventive dental care for children with conditions like autism and Down syndrome.
Each health center can receive up to $2 million to implement innovative strategies for addressing oral healthcare needs.
HRSA-supported centers will integrate oral health into primary care and provide services regardless of patients' ability to pay.
The initiative includes collaborative learning to identify effective practices for replication in other communities.

...more

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Digital Health

September 23, 2026

Evaluating the Precision of AI-Generated Answers to Frequently Asked Questions About Periodontal Scaling and Root Planing

Ahmed M. Kabli
September 23, 2026

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Nearly half of the global population is affected by periodontal disease, with severe cases impacting over 1 billion people worldwide.
Scaling and root planing (SRP) is the gold-standard non-surgical treatment for periodontal disease, involving plaque removal and root surface smoothing.
Patient compliance is crucial for the success of SRP, necessitating accurate information about post-operative care and sensitivity.
AI-generated responses to dental queries, particularly regarding SRP, have not been adequately evaluated for clinical accuracy and reliability.
The study aims to assess the accuracy of responses from two AI models, Gemini 3 Flash and ChatGPT GPT-5.2, to frequently asked questions about SRP.

...more

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Digital Health

September 18, 2026

Factors Influencing Parental Endorsement of Ongoing Engagement with an mHealth Chatbot: The Impact of Cognitive Beliefs and Perceived Quality

Wen-Jen Chang
Pei-Ching Chang
September 18, 2026

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The study investigates factors influencing parents' endorsement of their child's ongoing use of an mHealth chatbot for oral health.
Parental decision-making is crucial in determining children's continued engagement with digital health technologies.
The research combines the expectation-confirmation model and technology acceptance model to analyze parental support for mHealth.
Cognitive beliefs, perceived quality, and satisfaction are identified as key determinants of parents' intention to support continued use.
The study highlights a gap in research regarding caregiver-mediated continuance of mHealth interventions in pediatric contexts.

...more

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National Institutes Of Health

September 18, 2026

Dr. Jonathan E. Burke Appointed as Head of the National Institute of Dental and Craniofacial Research

September 18, 2026

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Objective: To announce the appointment of Dr. Jonathan E. Burke as the director of the National Institute of Dental and Craniofacial Research (NIDCR). Approach:

...more

Dr. Jonathan E. Burke has been appointed as the new director of the National Institute of Dental and Craniofacial Research.
Dr. Burke's appointment at NIDCR begins on September 20, 2026, as announced by NIH director Jay Bhattacharya.
He has over 30 years of clinical and academic leadership experience in oral and maxillofacial surgery.
NIDCR administers an annual budget of over $520 million for research on various oral and craniofacial health issues.
Dr. Burke has a background in TMJ pharmacology, implant devices, and has co-authored publications on craniofacial trauma.

...more

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MDSpire News

September 14, 2026

FDA broadens APDS treatment options

Kathryn Wighton
September 14, 2026
3 min

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The FDA has approved leniolisib (Joenja) for treating activated phosphoinositide 3-kinase delta syndrome in pediatric patients aged 4 to 11 years.
Leniolisib was initially approved for patients aged 12 years and older in 2023, targeting a rare genetic disorder affecting the immune system.
APDS can cause recurrent infections and enlargement of lymph nodes, tonsils, and spleen, potentially leading to airway and gastrointestinal obstruction.
Efficacy for older patients was demonstrated in a 12-week study showing reduced lymph node size and improved naïve B-cell counts with leniolisib.
Common adverse effects in younger patients include abdominal pain, respiratory infections, diarrhea, and headache; leniolisib is contraindicated in severe liver impairment.

...more

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MDSpire News

September 14, 2026

Robotic osteotomy may better match root geometry

Andrea Surnit
September 14, 2026
4 min

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An autonomous robotic osteotomy system may more accurately reproduce planned socket geometry for tooth autotransplantation than static guide-assisted preparation.
Robot-assisted preparation reduced mean apex deviation to 0.94 mm compared to 1.96 mm with static guide-assisted preparation.
The robotic approach showed significant advantages in angular deviation, with measurements of 1.86° versus 7.32° overall.
Overall preparation time was similar between techniques, approximately 759 seconds for robotic preparation and 833 seconds for static guidance.
The study suggests that robotic osteotomy may improve geometric fidelity and limit unnecessary material removal, especially in complex root anatomies.

...more

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