Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis - Report - DentalSpire
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Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis
Clinical Report: The Role of Trained Immunity in Linking Chronic Liver Disease and Periodontitis
Overview
This review explores the concept of trained immunity (TI) as a mechanism linking chronic liver disease and periodontitis through the proposed 'Liver-Gut-Immune-Oral Axis.'
Background
Chronic liver diseases affect over 800 million people globally, while periodontitis impacts 50% of adults. The concept of trained immunity offers a perspective on how innate immune responses can perpetuate inflammation across these systems.
Data Highlights
No numerical data or trial data presented in the article.
Key Findings
['Trained immunity allows innate immune cells to acquire long-term functional memory through metabolic and epigenetic reprogramming.', "The 'Liver-Gut-Immune-Oral Axis' is proposed as a framework connecting chronic liver disease and periodontitis.", 'Liver-gut dysfunction may induce bone marrow training, leading to hyper-reactive monocytes that exacerbate periodontal inflammation.', 'Conversely, periodontal pathogens can reprogram hematopoietic progenitors, accelerating liver disease progression.', 'Both pathways converge on shared metabolic-epigenetic reprogramming circuits.']
Clinical Implications
Understanding the interplay between these conditions can inform precision medicine approaches for inflammatory comorbidities.
Conclusion
The proposed framework of the 'Liver-Gut-Immune-Oral Axis' emphasizes the need for empirical validation of the mechanisms linking chronic liver disease and periodontitis through trained immunity.
