Understanding the burden of orofacial involvement and patient treatment preferences in systemic sclerosis: results from a large international survey - Report - DentalSpire

Exploring the Impact of Orofacial Symptoms and Treatment Preferences Among Systemic Sclerosis Patients: Findings from a Comprehensive Global Survey

  • By

  • Eleni Deligianni

  • Lee Shapiro

  • Deana Gibbs

  • Zsuzsanna H. McMahan

  • Michael Hughes

  • July 6, 2026

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Clinical Report: Exploring the Impact of Orofacial Symptoms in SSc Patients

Background

Orofacial manifestations in systemic sclerosis are common and can significantly affect patients' quality of life. Understanding patients' experiences and treatment preferences is crucial for enhancing care and outcomes.

Data Highlights

Findings indicate that common orofacial manifestations include xerostomia, facial appearance concerns, and restricted mouth opening. Patients reported more confidence in rheumatologists than dentists for managing orofacial symptoms. Significant oral health issues include periodontal disease, enamel wear, and dental caries. Up to 57.6% of patients experience involvement of the lip area, and 35.5% report oral mucosal involvement. Psychosocial impacts of orofacial disease were reported by 57.1% of respondents.

Key Findings

  • Common orofacial manifestations include xerostomia, facial appearance concerns, and restricted mouth opening.
  • Patients reported more confidence in rheumatologists than dentists for managing orofacial symptoms.
  • Significant oral health issues include periodontal disease, enamel wear, and dental caries.
  • Up to 57.6% of patients experience involvement of the lip area, and 35.5% report oral mucosal involvement.
  • Psychosocial impacts of orofacial disease were reported by 57.1% of respondents.

Clinical Implications

Healthcare providers should prioritize the assessment and management of orofacial symptoms in SSc patients. Enhanced collaboration between rheumatologists and dental professionals may improve patient outcomes and satisfaction.

Conclusion

Addressing orofacial manifestations in systemic sclerosis is essential for comprehensive patient care. Further research is needed to develop targeted strategies that meet the unmet needs of these patients.

Related Resources & Content

  1. Clinical Rheumatology, 2018 -- Guidelines for Comprehensive Management of Systemic Sclerosis: Insights from a Patient-Focused Multidisciplinary Study and Conference
  2. Drugs - Real World Outcomes, 2019 -- Exploring the Viability of an Online Survey to Evaluate Patient-Reported Outcomes and Satisfaction Among Ankylosing Spondylitis Patients Treated with Secukinumab
  3. Drugs - Real World Outcomes, 2025 -- Insights into Patient Perspectives on Psoriatic Disease in the United States: Findings from the Psoriasis and Beyond Global Research Initiative
  4. Oral and maxillofacial manifestations of systemic sclerosis - ScienceDirect
  5. EULAR recommendations for the treatment of systemic sclerosis: 2023 update - ScienceDirect
  6. Clinical Rheumatology — Factors Influencing the Selection of Intravenous Infusion versus Subcutaneous Injection in Systemic Lupus Erythematosus: A Study of Physician and Patient Attributes
  7. Oral and maxillofacial manifestations of systemic sclerosis - ScienceDirect
  8. EULAR recommendations for the treatment of systemic sclerosis: 2023 update - ScienceDirect
  9. https://www.dgrh.de/fileadmin/user_upload/downloads/04_lesen_downloads/Sys_Sklerose_Kurzfassung.pdf
  10. The effect of exercise program applied to patients with scleroderma on functional outcomes: A Randomized Controlled Trial - PubMed

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