To systematically map existing oral frailty risk prediction models for older adults, focusing on model development methods, outcome definitions, retained predictors, validation strategies, predictive performance, risk of bias, and applicability.
Approach:
Search Strategy: Databases searched included PubMed, Web of Science Core Collection, Embase, CINAHL, ProQuest, the Cochrane Library, China National Knowledge Infrastructure, Wanfang, VIP, and SinoMed from inception to April 10, 2023.
Key Findings:
Seventeen studies included, mostly cross-sectional and concentrated in China.
Oral frailty definitions and assessment approaches varied; prevalence ranged from 25.50% to 92.50%.
Logistic regression was commonly used for model development, with nomograms for displaying prediction tools.
Frequent predictors included age, nutrition-related factors, swallowing difficulty, frailty, and denture-related factors.
Fifteen studies reported internal validation; only two provided external validation.
Area under the receiver operating characteristic curve ranged from 0.725 to 0.985.
Court-documented maltreatment was associated with small differences in GrimAge and DunedinPACE in sixth decade of life, but neither difference was statistically significant.
Analysis of East Asian genetic data found a modest inverse association between rheumatoid arthritis susceptibility and periodontitis risk, though researchers said the findings require confirmation in independent cohorts.
