To identify discriminatory biomarkers between diabetic periodontitis (DMCP) and chronic periodontitis (CP) to provide an evidence-based foundation for improved clinical management.
Approach:
Key Findings:
DMCP group had significantly higher levels of very low-density lipoprotein (VLDL) compared to CP (SMD: 0.91; 95%CI: 0.43 to 1.39; P<0.001).
Elevated levels of interleukin-8 (IL-8) (SMD: 0.38; 95%CI: 0.06 to 0.70; P=0.021) and high-sensitivity C-reactive protein (hs-CRP) (SMD: 2.56; 95%CI: 0.31 to 4.82; P=0.026) were found in the DMCP group.
Significant decreases in catalase (CAT) (SMD: -0.31; 95%CI: -0.58 to -0.05; P=0.021) and oxidized glutathione (GSSG) (SMD: -1.16; 95%CI: -1.76 to -0.55; P < 0.001) levels were observed in the DMCP group.
Higher levels of nitric oxide synthase (NOS) (SMD: 0.58; 95%CI: 0.11 to 1.05; P=.016) and 4-hydroxynonenal (4-HNE) (SMD: 7.05; 95%CI: 5.07 to 9.03; P < 0.001) were noted in the DMCP group.
Other biomarkers such as body mass index, eotaxin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and plasminogen activator inhibitor-1 were significantly elevated in the DMCP group.
Interpretation:
Significant differences in biomarkers related to lipid metabolism, inflammatory response, and oxidative stress were observed between DMCP and CP.
Limitations:
The study is limited to the available literature and may not encompass all potential biomarkers.
Variability in study designs and populations may affect the generalizability of the findings.
Conclusion:
Key indicators demonstrating robust differences include VLDL, 4-HNE, CAT, GSSG, NOS, IL-8, hs-CRP, and C-peptide.
Study found species-specific differences in biofilm -forming capacity and antimicrobial susceptibility among supragingival bacterial isolates from patients with active dental caries.
