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1
Polystyrene nanoplastics (PS-NPs) disrupt the oral-gut microbiota axis, leading to inflammation and accelerated aging in young mice.
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2
Exposure to PS-NPs significantly increases cellular senescence markers p21Cip1/Waf and p16Ink4a in the lungs and liver of young mice.
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3
PS-NPs promote the release of inflammatory cytokines IL-1β, IL-6, and TNF-α by modulating the p38 MAPK signaling pathway.
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16S rRNA sequencing reveals that PS-NPs exposure causes dysbiosis in oral and intestinal microbiota, altering microbial diversity.
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5
The study provides insights into the toxicity of nanoplastics and suggests potential strategies for mitigating their health impacts.
