Characteristics and Long-Term Outcomes of Asymptomatic Corticotroph Adenomas: A Retrospective Analysis of Clinical, Radiological, and Pathological Data

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Silent corticotroph adenomas (SCAs) are a subtype of non-functioning pituitary adenomas that lack clinical symptoms of hormone hypersecretion.
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SCAs are often misclassified due to their indistinguishable radiological features from other non-functioning pituitary adenomas.
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Despite their silent presentation, SCAs exhibit invasive behavior and have a higher risk of postoperative recurrence compared to other non-functioning adenomas.
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Accurate preoperative identification of SCAs is crucial for guiding treatment decisions and developing individualized management strategies.
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The study aimed to identify independent preoperative factors to distinguish SCAs from other non-functioning pituitary adenomas and evaluate postoperative prognostic indicators.

Bmc Endocrine Disorders

by Yuhui Chen, Yang Yang, Heng Zhang, Tianshun Feng, Liangfeng Wei, Shousen Wang
December 1, 2025

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