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1
The oral mucosa is a critical immune barrier that protects against pathogens and maintains both local oral health and systemic well-being.
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2
Barrier remodeling involves structural, immunological, ecological, and functional processes that determine the restoration of homeostasis or progression to dysfunction.
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3
Dysfunctional oral mucosa can exacerbate local lesions and worsen systemic diseases through the oral-systemic axis.
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4
Cutting-edge technologies have enhanced understanding of oral barrier remodeling, leading to novel therapeutic strategies for restoration.
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5
Research limitations include a lack of integrated mechanistic studies and standardized protocols, necessitating collaboration between basic research and clinical practice.
