β-lapachone reduces cell viability, migration, and epithelial–mesenchymal transition in mammary tumor spheroids - Takeaways - DentalSpire

β-lapachone reduces cell viability, migration, and epithelial–mesenchymal transition in mammary tumor spheroids

  • By

  • Laura Lacerda Coelho

  • Matheus Menezes Vianna

  • Debora Moraes da Silva

  • Beatriz Matheus de Souza Gonzaga

  • Roberto Rodrigues Ferreira

  • Claudia Mara Lara Melo Coutinho

  • Fatima Cristina Mendes Magalhães

  • Edmilson José Maria

  • Rodrigo Rodrigues de Oliveira

  • Pedro Paulo de Abreu Manso

  • Marcelo Alex de Carvalho

  • Fernando Regla Vargas

  • Luciana Ribeiro Garzoni

  • November 26, 2025

  • 0 min

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  • 1

    Breast cancer is the most common cancer in women, with metastasis contributing to poor prognosis and high mortality rates.

  • 2

    β-lapachone, derived from Tabebuia avellanedae, shows promise as an anticancer agent with effects on various tumors, including breast cancer.

  • 3

    The study utilized a 3D model of mammary tumor spheroids to evaluate the cytotoxic and antimetastatic effects of β-lapachone.

  • 4

    Results indicated that β-lapachone significantly reduced cell viability, migration, and inhibited epithelial–mesenchymal transition in mammary tumor spheroids.

  • 5

    The findings support the potential of β-lapachone as a therapeutic agent for improving outcomes in breast cancer treatment.

Original Source(s)

β-lapachone reduces cell viability, migration, and epithelial–mesenchymal transition in mammary tumor spheroids

  • by Laura Lacerda Coelho, Matheus Menezes Vianna, Debora Moraes da Silva, Beatriz Matheus de Souza Gonzaga, Roberto Rodrigues Ferreira, Claudia Mara Lara Melo Coutinho, Fatima Cristina Mendes Magalhães, Edmilson José Maria, Rodrigo Rodrigues de Oliveira, Pedro Paulo de Abreu Manso, Marcelo Alex de Carvalho, Fernando Regla Vargas, Luciana Ribeiro Garzoni

  • November 26, 2025

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