Conexiant’s news site is now MDSpire News. Learn more
Advertisement
Oral Toxicities With Antibody-Drug Conjugates: What Physicians Should Know
Antibody-drug conjugates (ADCs) have become an increasingly important part of treatment for several advanced cancers, pairing a tumor-targeting antibody with a cytotoxic payload.
In a retrospective multicenter cohort of 207 patients with advanced cancer treated with TROP2- or HER2-directed ADCs, 22.7% developed at least 1 oral toxicity.
2
Oral mucositis was more common with TROP2-directed than HER2-directed ADCs (14.8% vs 5.4%), and adjusted odds were approximately 3 times higher with TROP2 therapy.
3
Dysgeusia and xerostomia were more common with HER2-directed ADCs, although differences between treatment groups were not statistically significant.
4
Topical corticosteroids did not improve existing mucositis or prevent new lesions, whereas 4 patients treated with oral cryotherapy had symptomatic improvement and fewer new ulcers.
5
The retrospective design, predominance of patients with breast cancer, and reliance on medical records may limit generalizability and have led to underreporting of oral toxicities.
