Biomarkers for differentiating diabetic periodontitis from chronic periodontitis: a systematic review and meta-analysis - Takeaways - DentalSpire

Biomarkers for differentiating diabetic periodontitis from chronic periodontitis: a systematic review and meta-analysis

  • By

  • Li Zhang

  • Ru Li

  • Shengnan Zhang

  • Wenhui Kong

  • Peipei Zhang

  • Wenyue Zhang

  • Jing Sun

  • June 10, 2026

  • 0 min

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  • 1

    Diabetes-related periodontitis (DMCP) and chronic periodontitis (CP) differ significantly in clinical presentation and treatment outcomes.

  • 2

    The meta-analysis included 33 studies with 970 DMCP patients and 905 CP patients to identify biomarkers for differentiation.

  • 3

    DMCP patients showed significantly higher levels of very low-density lipoprotein (VLDL) and inflammatory markers like IL-8 and hs-CRP.

  • 4

    Oxidative stress markers such as catalase (CAT) and oxidized glutathione (GSSG) were significantly lower in DMCP patients.

  • 5

    Key biomarkers for distinguishing DMCP from CP include VLDL, 4-hydroxynonenal (4-HNE), CAT, GSSG, NOS, IL-8, hs-CRP, and C-peptide.

Original Source(s)

Biomarkers for differentiating diabetic periodontitis from chronic periodontitis: a systematic review and meta-analysis

  • by Li Zhang, Ru Li, Shengnan Zhang, Wenhui Kong, Peipei Zhang, Wenyue Zhang, Jing Sun

  • June 10, 2026

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