Removal of CD5 on T cells alters their differentiation and cytokine production in an in vitro model investigating effects of P. gingivalis LPS on oral epithelial and immune cells

1

Periodontal disease affects nearly half of adults over 30 in the U.S., leading to significant inflammation and potential systemic health issues.
2

CD5 is a glycoprotein receptor on T cells that modulates TCR signaling, influencing T cell activation and differentiation.
3

CD5 knockout T cells show increased activation and effector/memory formation compared to wildtype T cells in response to P. gingivalis LPS.
4

The study highlights the role of CD5 in regulating inflammation during periodontal disease, providing insights for potential therapeutic strategies.
5

Understanding the immune response in periodontal disease may help develop new immunotherapies and improve patient outcomes.

Frontiers In Immunology

by Carlos Moreno, Alina Svitlana Rodriguez Bezruchko, Dallin Cardon, Claudia M. Tellez Freitas, K. Scott Weber
June 10, 2026

1