Patterns of Genetic Alterations and Prognostic Implications of Homologous Recombination Repair Genes in Gliomas

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Gliomas are the most common primary malignant brain tumors, characterized by diverse molecular and histological features affecting treatment and prognosis.
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Homologous recombination repair (HRR) is crucial for DNA repair, and mutations in HRR genes can lead to homologous recombination deficiency (HRD) in various cancers.
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The study analyzed 1352 glioma samples to investigate the molecular characteristics and survival outcomes related to HRR loss of function (LOF) mutations.
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Patients were categorized into Germline HRR-LOF, Somatic HRR-LOF, and NonHRR-LOF groups, with significant implications for treatment strategies.
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The research also explored the immune microenvironment characteristics of glioma patients with HRR LOF, highlighting potential therapeutic targets.

Bmc Cancer

by Hongmin Bai, Yaqin Liu, Cheng Ji, Qin Zhang, Ningning Luo, Xing Zhang, Zhiming Zheng
December 26, 2025

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