Telomerase-mediated immortalization preserves the anti-inflammatory activity of dental pulp stem cell extracellular vesicles - Takeaways - DentalSpire

Telomerase-mediated immortalization preserves the anti-inflammatory activity of dental pulp stem cell extracellular vesicles

  • By

  • Sadiq Umar

  • Yu Lu

  • Sherly Makar

  • Koushik Debnath

  • Wang Li

  • Sreeparna Chakraborty

  • Jalees Rehman

  • Sriram Ravindran

  • June 10, 2026

  • 0 min

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  • 1

    hTERT-immortalized dental pulp stem cells (DPSCs) maintain their multi-lineage differentiation potential while extending replicative lifespan.

  • 2

    Extracellular vesicles (EVs) from hTERT-immortalized DPSCs exhibit similar size, morphology, and immunomodulatory activity compared to naïve DPSC-derived EVs.

  • 3

    Both naïve and immortalized DPSC-derived EVs effectively suppress pro-inflammatory cytokines in activated macrophages without altering EV uptake.

  • 4

    In vivo studies show that EVs from both sources reduce pulmonary edema and inflammatory responses in a murine model of acute lung injury.

  • 5

    hTERT-mediated immortalization provides a scalable source of bioactive EVs with consistent anti-inflammatory properties for therapeutic applications.

Original Source(s)

Telomerase-mediated immortalization preserves the anti-inflammatory activity of dental pulp stem cell extracellular vesicles

  • by Sadiq Umar, Yu Lu, Sherly Makar, Koushik Debnath, Wang Li, Sreeparna Chakraborty, Jalees Rehman, Sriram Ravindran

  • June 10, 2026

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