Host-microbiome-immune disequilibrium in oral disease: mechanisms, dysbiosis, and precision therapeutics - Takeaways - DentalSpire

Host-microbiome-immune disequilibrium in oral disease: mechanisms, dysbiosis, and precision therapeutics

  • By

  • Ming Lv

  • Wenya Xu

  • Tong Wang

  • Kehao Mou

  • Zijian Ni

  • Qiudi Tu

  • Jingkun Zhang

  • Xue Wu

  • Siyuan Song

  • Gang Cheng

  • June 22, 2026

  • 0 min

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  • 1

    The oral cavity contains a diverse microbial ecosystem that interacts with host immunity and epithelial barriers.

  • 2

    Dysbiosis disrupts oral homeostasis, leading to the expansion of pathobionts and contributing to oral diseases.

  • 3

    Current models of oral disease should focus on ecological disruption and host responses rather than single-pathogen infections.

  • 4

    Emerging technologies, including microbiome-modulating therapies and AI, are advancing precision therapeutic development.

  • 5

    Oral diseases should be viewed as disorders of host-microbiome-immune disequilibrium, necessitating integrated strategies for management.

Original Source(s)

Host-microbiome-immune disequilibrium in oral disease: mechanisms, dysbiosis, and precision therapeutics

  • by Ming Lv, Wenya Xu, Tong Wang, Kehao Mou, Zijian Ni, Qiudi Tu, Jingkun Zhang, Xue Wu, Siyuan Song, Gang Cheng

  • June 22, 2026

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