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1
Head and neck cancer has a global burden of approximately 880,000 new cases annually, with radiotherapy used in about 75% of treatments.
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2
Osteoradionecrosis (ORN) occurs in 7-10% of patients and is characterized by severe complications affecting quality of life.
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3
The NTCP model developed by van Dijk et al. identified D30% and pre-RT dental extraction as key predictors of ORN.
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4
The WAFT model introduced a time-to-event framework, showing that each additional Gray of radiation shortens the time to ORN onset.
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5
Methodological limitations in existing NTCP models include insufficient cohort diversity and inadequate characterization of RT protocols.
