4 Topic Commentaries

Natural Alternatives: Potential of Non-Human-Derived Exosomes in Treating Periodontitis

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  Huang-Ge Zhang, DVM, MD, PhD

  Endowed Professor of Microbiology and Immunology; Founders Chair in Cancer Research

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  University of Louisville

  Our exosomes come from fruit or other edible plants — something good for you, that you buy in the grocery store and that humans have eaten forever. And, they don't require synthetic formulation.

  [Source]
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  Janos Zempleni, PhD

  Willa Cather Professor of Molecular Nutrition

  •

  University of Nebraska–Lincoln

  The beauty is we can take the exosomes out of cow’s milk. We have an unlimited supply of the vehicle, we just have to modify it by attaching our synthetically made peptides. In theory, we could deliver these exosomes in large quantities tomorrow.

  [Source]
• 

  Tushar C. Patel, M.B., Ch.B.

  Dean for Research; Transplant Hepatologist

  •

  Mayo Clinic (Florida)

  EVs are released by many types of cells, and can even be found in most if not all bodily fluids. But in order to use them for cancer treatment, large quantities of EVs need to be available.

  [Source]
• 

  Kenneth W. Witwer, PhD

  Associate Professor of Molecular and Comparative Pathobiology and Neurology

  •

  Johns Hopkins University School of Medicine

  We can put things on the surface of vesicles that will adjust the effects of the vaccine, or we can target vesicles to specific cells. We can even add factors that help the extracellular vesicle avoid being cleared too quickly from the body.

  [Source]