Acute cell‑death and lysosomal stress responses to nicotine and cigarette smoke extract in human mesenchymal stromal cells - Scorecard - DentalSpire

Acute cell‑death and lysosomal stress responses to nicotine and cigarette smoke extract in human mesenchymal stromal cells

  • By

  • Anni Junttila

  • Janne Heikkinen

  • Elina Kylmäoja

  • Ayman Hawash

  • Pirjo Åström

  • Petri Lehenkari

  • Sanna Palosaari

  • May 20, 2026

  • 0 min

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Clinical Scorecard: Responses of Human Mesenchymal Stromal Cells to Acute Cell Death and Lysosomal Stress Induced by Nicotine and Cigarette Smoke Extracts

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationUsers of smokeless tobacco products, smokers, and non-smokers using nicotine products.
Care Setting

Key Highlights

  • Clarify the mechanism by which cigarette smoke exacerbates bone loss.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Regular follow-ups for patients using nicotine pouches every 3-6 months.
      • Evaluate MSC function in smokers at each dental visit.

      Risks

        Patient & Prescribing Data

        High nicotine concentrations can lead to cell death and impaired tissue regeneration; consider side effects of alternative therapies.

        Clinical Best Practices

        • Educate patients on the risks of nicotine use on oral and bone health; provide brochures or links to reliable online resources.
        • Implement regular dental check-ups for early detection of mucosal pathology.

        Related Resources & Content

        Original Source(s)

        Acute cell‑death and lysosomal stress responses to nicotine and cigarette smoke extract in human mesenchymal stromal cells

        • by Anni Junttila, Janne Heikkinen, Elina Kylmäoja, Ayman Hawash, Pirjo Åström, Petri Lehenkari, Sanna Palosaari

        • May 20, 2026

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