Dual role of N4BP1 in neutrophil–epithelial crosstalk in periodontitis
By
Yuqiang Sun
ZiHan Shen
Wenyu Zhen
Fei Xu
Yutong Lu
Yufei Pan
Dawei Mi
Shouzheng Ma
Wei Li
Wansu Sun
Jintao Yu
Hengguo Zhang
May 28, 2026
Clinical Scorecard: N4BP1's Dual Function in Neutrophil and Epithelial Interactions During Periodontitis
At a Glance
Category Detail
Condition Key Mechanisms N4BP1 regulates interactions between neutrophils and epithelial cells. Target Population Care Setting
Key Highlights
Identification of a low-density neutrophil subset (LDN-1) linked to periodontitis. N4BP1 plays a dual role in epithelial cells and neutrophils, affecting inflammatory signaling. Downregulation of N4BP1 in epithelial cells leads to impaired mucosal barrier integrity. N4BP1 modulates both pro-inflammatory and anti-inflammatory pathways in neutrophils. Guideline-Based Recommendations
Diagnosis
Utilize single-cell RNA sequencing for detailed immune profiling in periodontitis. Management
Monitoring & Follow-up
Assess neutrophil subsets and N4BP1 expression levels during disease progression. Risks
Increased inflammatory tissue damage associated with N4BP1 dysregulation. Patient & Prescribing Data
Patients with severe chronic periodontitis
Initial periodontal therapy may alter neutrophil profiles and N4BP1 expression.
Clinical Best Practices
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