Evaluation of a multi-component mucoadhesive buccal patch: cytokine-associated inflammatory responses and tissue remodeling in experimental models - Scorecard - DentalSpire

Evaluation of a multi-component mucoadhesive buccal patch: cytokine-associated inflammatory responses and tissue remodeling in experimental models

  • By

  • Rekha Rani Kokkanti

  • Sandhiya Viswanathan

  • Nandita Parida

  • Soumyajit Biswas

  • Gajraj Singh Kushwaha

  • Pratap Kumar Deheri

  • Alok Kumar Panda

  • Abikshyeet Panda

  • Atul Anand Bajoria

  • Srinivas Patnaik

  • May 28, 2026

  • 0 min

Share

Clinical Scorecard: Assessment of a multi-faceted mucoadhesive buccal patch: inflammatory cytokine responses and tissue remodeling in experimental studies

At a Glance

CategoryDetail
ConditionOral submucous fibrosis (OSMF)
Key MechanismsDysregulated cytokine signaling, inflammation, and fibrosis
Target PopulationPatients with oral submucous fibrosis
Care SettingClinical and experimental research settings

Key Highlights

  • Localized buccal delivery platform incorporating isotretinoin, bromelain, and limonene
  • Altered expression of cytokine associated inflammatory markers (IL-6, TNF-α, TGF-β, IL-2)
  • Alteration of extracellular matrix related responses, including MMP-2 expression
  • Effects observed in LPS induced acute inflammatory in vitro models
  • Reduced collagen deposition and functional improvements in an in vivo chemically induced inflammation model

Guideline-Based Recommendations

Diagnosis

  • Assessment of inflammatory and fibrotic markers in oral mucosa

Management

  • Utilization of mucoadhesive buccal patches for localized treatment

Monitoring & Follow-up

  • Evaluation of cytokine levels and tissue remodeling indicators

Risks

  • Potential for persistent inflammation and fibrosis if untreated

Patient & Prescribing Data

Individuals diagnosed with oral submucous fibrosis

Combination therapy with isotretinoin, bromelain, and limonene may modulate inflammatory responses

Clinical Best Practices

  • Implement localized treatment strategies for OSMF
  • Monitor cytokine levels and tissue changes during treatment
  • Consider multi-component formulations for comprehensive management

Related Resources & Content

Original Source(s)

Evaluation of a multi-component mucoadhesive buccal patch: cytokine-associated inflammatory responses and tissue remodeling in experimental models

  • by Rekha Rani Kokkanti, Sandhiya Viswanathan, Nandita Parida, Soumyajit Biswas, Gajraj Singh Kushwaha, Pratap Kumar Deheri, Alok Kumar Panda, Abikshyeet Panda, Atul Anand Bajoria, Srinivas Patnaik

  • May 28, 2026

Related Content

Beyond traditional metrics: the holistic role of multisource feedback in comprehensive dental clinical education

Medicaid Mental Health and Substance Use: Expansion Trends and the Fiscal Pressure Ahead

Assessment of online information about osteomyelitis of jaw: An infodemiologic study