Efficacy of a Single Dose of Albendazole for Treating Ascaris lumbricoides in Schoolchildren in Northwest Ethiopia: An Open-Label Trial Examining Re-Infection Rates and Contributing Factors - Scorecard - DentalSpire
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Efficacy of a Single Dose of Albendazole for Treating Ascaris lumbricoides in Schoolchildren in Northwest Ethiopia: An Open-Label Trial Examining Re-Infection Rates and Contributing Factors
Clinical Scorecard: Efficacy of a Single Dose of Albendazole for Treating Ascaris lumbricoides in Schoolchildren in Northwest Ethiopia: An Open-Label Trial Examining Re-Infection Rates and Contributing Factors
At a Glance
Category
Detail
Condition
Key Mechanisms
Transmission via fecal-oral route; impacts digestion and absorption of nutrients, leading to malnutrition and other health issues.
Target Population
Care Setting
Key Highlights
A. lumbricoides is a major soil-transmitted helminth affecting schoolchildren.
Single-dose Albendazole (400 mg) is commonly used for treatment.
Re-infection can occur as early as 2 months post-treatment.
Efficacy monitoring is crucial due to potential drug resistance.
Poor hygiene and sanitation practices contribute to ongoing transmission.
Hygiene education is essential to prevent re-infection.
Guideline-Based Recommendations
Diagnosis
Microscopic confirmation of A. lumbricoides infection using Kato-Katz technique.
Management
Mass drug administration (MDA) of Albendazole for at-risk populations.
Implement hygiene education alongside MDA.
Monitoring & Follow-up
Regular assessment of drug efficacy and re-infection rates, including specific monitoring protocols.
Risks
Potential emergence of drug-resistant A. lumbricoides strains.
Patient & Prescribing Data
School-age children (7-14 years) with confirmed A. lumbricoides infection.
Single-dose Albendazole is effective but requires monitoring for re-infection, including follow-up assessments.
Clinical Best Practices
Implement hygiene education alongside MDA to reduce transmission.
Conduct periodic evaluations of drug efficacy and resistance.
Target interventions based on identified risk factors for re-infection.
Engage the community in hygiene education initiatives.
