DENTALE: a validated Dentofacial EvaluatioN Tool to standardize radiological Assessment of Late dental and maxillofacial adverse Effects following treatment for pediatric rhabdomyosarcoma - Summary - DentalSpire

DENTALE: a validated Dentofacial EvaluatioN Tool to standardize radiological Assessment of Late dental and maxillofacial adverse Effects following treatment for pediatric rhabdomyosarcoma

  • By

  • Koen B. Krommenhoek

  • Reinier C. Hoogeveen

  • E. Foster-Thomas

  • Willem M. M. Fennis

  • Frédérique J. M. San Giorgi

  • Matthew Krasin

  • Mark N. Gaze

  • Olga Slater

  • Gillian A. Whitfield

  • Daniel J. Indelicato

  • Henry C. Mandeville

  • Shermaine Pan

  • Marianne C. Aznar

  • Johannes H. M. Merks

  • Alfred G. Becking

  • Marinka L. F. Hol

  • May 22, 2026

  • 0 min

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Objective:

To develop and validate a standardized radiographic evaluation tool, DENTALE, for assessing late dental adverse effects in survivors of childhood cancer.

Key Findings:
  • Interobserver reliability showed good to excellent agreement (ICC: 0.857–0.939).
  • DENTALE achieved 100% sensitivity and 90.0% specificity for specialized dental care referral decisions using a threshold score of 16 points.
  • Positive and negative predictive values were 94.6% and 100%, respectively.
Interpretation:

Remove or rephrase to eliminate unsupported conclusions.

Limitations:
  • The study focused on a specific cohort of rhabdomyosarcoma survivors, which may limit generalizability.
  • Further validation in diverse populations and treatment modalities is necessary.
Conclusion:

Revise to focus solely on findings without unsupported claims.

Original Source(s)

DENTALE: a validated Dentofacial EvaluatioN Tool to standardize radiological Assessment of Late dental and maxillofacial adverse Effects following treatment for pediatric rhabdomyosarcoma

  • by Koen B. Krommenhoek, Reinier C. Hoogeveen, E. Foster-Thomas, Willem M. M. Fennis, Frédérique J. M. San Giorgi, Matthew Krasin, Mark N. Gaze, Olga Slater, Gillian A. Whitfield, Daniel J. Indelicato, Henry C. Mandeville, Shermaine Pan, Marianne C. Aznar, Johannes H. M. Merks, Alfred G. Becking, Marinka L. F. Hol

  • May 22, 2026

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