Dual role of N4BP1 in neutrophil–epithelial crosstalk in periodontitis - Summary - DentalSpire

Dual role of N4BP1 in neutrophil–epithelial crosstalk in periodontitis

  • By

  • Yuqiang Sun

  • ZiHan Shen

  • Wenyu Zhen

  • Fei Xu

  • Yutong Lu

  • Yufei Pan

  • Dawei Mi

  • Shouzheng Ma

  • Wei Li

  • Wansu Sun

  • Jintao Yu

  • Hengguo Zhang

  • May 28, 2026

  • 0 min

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Objective:

To identify disease-associated immune cell subsets and gene regulatory mechanisms in periodontitis, focusing on the role of N4BP1 in neutrophil and epithelial interactions.

Key Findings:
  • Identification of a transcriptionally defined neutrophil subset (LDN-1) with aberrant epithelial interactions.
  • N4BP1 downregulation in epithelial cells impaired mucosal barrier integrity.
  • N4BP1 in LDN-1 suppressed both pro-inflammatory and anti-inflammatory signaling pathways.
Interpretation:

Remove this section as it contains unsupported claims.

Limitations:
  • Further interventional validation is required to confirm therapeutic potential.
  • Study primarily based on murine models and human cell lines, which may not fully replicate in vivo human conditions.
Conclusion:

Revise to eliminate any implications about therapeutic potential.

Original Source(s)

Dual role of N4BP1 in neutrophil–epithelial crosstalk in periodontitis

  • by Yuqiang Sun, ZiHan Shen, Wenyu Zhen, Fei Xu, Yutong Lu, Yufei Pan, Dawei Mi, Shouzheng Ma, Wei Li, Wansu Sun, Jintao Yu, Hengguo Zhang

  • May 28, 2026

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