Predicting survival in oral squamous cell carcinoma via integrated analysis of tumor budding and tertiary lymphoid structures - Takeaways - DentalSpire

Predicting survival in oral squamous cell carcinoma via integrated analysis of tumor budding and tertiary lymphoid structures

  • By

  • Zhuqin Xiang

  • Yaqi Huang

  • Bokai Yun

  • Dongpeng Li

  • Fengshuo Liu

  • Junliang Liu

  • Nan Xie

  • Zehang Zhuang

  • Jinsong Hou

  • Cheng Wang

  • June 3, 2026

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  • 1

    The study assessed the prognostic value of tumor budding (TB) and tertiary lymphoid structures (TLS) in oral squamous cell carcinoma (OSCC).

  • 2

    High-grade TB was linked to poor survival outcomes, while high-maturation TLS correlated with favorable prognosis in OSCC patients.

  • 3

    The TB/TLS index demonstrated superior prognostic ability compared to individual biomarkers in predicting OSCC survival.

  • 4

    A nomogram incorporating the TB/TLS index and clinicopathological factors was developed, showing reliable predictive performance.

  • 5

    External validation confirmed the nomogram's moderate predictive performance despite significant baseline differences between cohorts.

Original Source(s)

Predicting survival in oral squamous cell carcinoma via integrated analysis of tumor budding and tertiary lymphoid structures

  • by Zhuqin Xiang, Yaqi Huang, Bokai Yun, Dongpeng Li, Fengshuo Liu, Junliang Liu, Nan Xie, Zehang Zhuang, Jinsong Hou, Cheng Wang

  • June 3, 2026

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