Multidimensional exposure architecture shapes vaping-associated transcriptomic dysregulation in oral epithelium - Takeaways - DentalSpire

Multidimensional exposure architecture shapes vaping-associated transcriptomic dysregulation in oral epithelium

  • By

  • Jessica George

  • Stella Tommasi

  • Niccolo Pabustan

  • Daria M. Kessler

  • Zairah L. Thomas

  • Lourdes Baezconde-Garbanati

  • Kimberly D. Siegmund

  • Ahmad Besaratinia

  • June 1, 2026

  • 0 min

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  • 1

    Vaping and smoking both cause transcriptomic dysregulation in oral epithelial cells compared to non-users.

  • 2

    Differential gene expression analysis revealed overlapping and unique genes affected by vaping and smoking.

  • 3

    Device generation and flavor type significantly influence gene expression variability among vapers.

  • 4

    A higher percentage of smoking-associated genes showed consistent dose-dependent responses compared to vaping.

  • 5

    Incorporating multidimensional exposure metrics may enhance regulatory evaluations of e-cigarette health impacts.

Original Source(s)

Multidimensional exposure architecture shapes vaping-associated transcriptomic dysregulation in oral epithelium

  • by Jessica George, Stella Tommasi, Niccolo Pabustan, Daria M. Kessler, Zairah L. Thomas, Lourdes Baezconde-Garbanati, Kimberly D. Siegmund, Ahmad Besaratinia

  • June 1, 2026

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