Dual role of N4BP1 in neutrophil–epithelial crosstalk in periodontitis - Takeaways - DentalSpire

Dual role of N4BP1 in neutrophil–epithelial crosstalk in periodontitis

  • By

  • Yuqiang Sun

  • ZiHan Shen

  • Wenyu Zhen

  • Fei Xu

  • Yutong Lu

  • Yufei Pan

  • Dawei Mi

  • Shouzheng Ma

  • Wei Li

  • Wansu Sun

  • Jintao Yu

  • Hengguo Zhang

  • May 28, 2026

  • 0 min

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  • 1

    Periodontitis is a chronic inflammatory disease characterized by immune dysregulation, with neutrophils playing a central role.

  • 2

    A transcriptionally defined neutrophil subset, LDN-1, exhibits aberrant interactions with epithelial cells mediated by N4BP1 dysregulation.

  • 3

    N4BP1 has a dual role: downregulation in epithelial cells impairs barrier integrity, while upregulation in LDN-1 suppresses inflammatory signaling.

  • 4

    The study integrated single-cell RNA sequencing and Mendelian randomization to identify immune cell subsets and gene regulatory mechanisms.

  • 5

    N4BP1 is identified as a critical molecular candidate for coordinating epithelial barrier function and neutrophil activity in periodontitis.

Original Source(s)

Dual role of N4BP1 in neutrophil–epithelial crosstalk in periodontitis

  • by Yuqiang Sun, ZiHan Shen, Wenyu Zhen, Fei Xu, Yutong Lu, Yufei Pan, Dawei Mi, Shouzheng Ma, Wei Li, Wansu Sun, Jintao Yu, Hengguo Zhang

  • May 28, 2026

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