Evaluation of a multi-component mucoadhesive buccal patch: cytokine-associated inflammatory responses and tissue remodeling in experimental models - Takeaways - DentalSpire

Evaluation of a multi-component mucoadhesive buccal patch: cytokine-associated inflammatory responses and tissue remodeling in experimental models

  • By

  • Rekha Rani Kokkanti

  • Sandhiya Viswanathan

  • Nandita Parida

  • Soumyajit Biswas

  • Gajraj Singh Kushwaha

  • Pratap Kumar Deheri

  • Alok Kumar Panda

  • Abikshyeet Panda

  • Atul Anand Bajoria

  • Srinivas Patnaik

  • May 28, 2026

  • 0 min

Share

  • 1

    The study evaluated a mucoadhesive buccal patch containing isotretinoin, bromelain, and limonene for treating oral submucous fibrosis (OSMF).

  • 2

    Treatment with the buccal patch reduced inflammatory cytokines IL-6, TNF-α, and MMP-2 in LPS-induced acute inflammatory models.

  • 3

    In vivo results showed reduced collagen deposition and improved tissue architecture, indicating attenuation of fibrotic progression.

  • 4

    Bromelain retained enzymatic activity, demonstrating concentration and time-dependent collagen degradation in the formulation.

  • 5

    The findings suggest potential for localized intervention in OSMF, highlighting the need for further studies on cytokine modulation.

Original Source(s)

Evaluation of a multi-component mucoadhesive buccal patch: cytokine-associated inflammatory responses and tissue remodeling in experimental models

  • by Rekha Rani Kokkanti, Sandhiya Viswanathan, Nandita Parida, Soumyajit Biswas, Gajraj Singh Kushwaha, Pratap Kumar Deheri, Alok Kumar Panda, Abikshyeet Panda, Atul Anand Bajoria, Srinivas Patnaik

  • May 28, 2026

Related Content

Revisiting B-cell targeted therapies in rheumatoid arthritis: from paradoxical biology to deep immune reset

Why health information technology safety problems remain invisible

Oral myiasis complicating endotracheal intubation in a diabetic patient: a case report