Spatial transcriptomics uncovers TAC-OGEs heterogeneity and FN1/MMP9 signature in ameloblastoma - Takeaways - DentalSpire

Spatial transcriptomics uncovers TAC-OGEs heterogeneity and FN1/MMP9 signature in ameloblastoma

  • By

  • Yitong Wang

  • Haiyang Li

  • Chunyu Zhang

  • Xin Peng

  • Jianping Liu

  • Wenya Du

  • Yao Yu

  • Yali Hou

  • Xiangjun Li

  • April 30, 2026

  • 0 min

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  • 1

    This study utilized spatial transcriptomic sequencing to analyze the cellular heterogeneity of ameloblastoma.

  • 2

    Seven primary cell clusters were identified, including TAC-OGEs, which showed increased FN1 and MMP9 expression at the invasive front.

  • 3

    TAC-OGEs exhibited seven distinct subclusters with a spatial gradient from the tumor core to the periphery.

  • 4

    Immunohistochemical validation confirmed the spatial expression patterns of FN1 and MMP9 at the tumor-stroma interface.

  • 5

    Targeting TAC-OGE-associated processes may offer a new therapeutic strategy for managing ameloblastoma.

Original Source(s)

Spatial transcriptomics uncovers TAC-OGEs heterogeneity and FN1/MMP9 signature in ameloblastoma

  • by Yitong Wang, Haiyang Li, Chunyu Zhang, Xin Peng, Jianping Liu, Wenya Du, Yao Yu, Yali Hou, Xiangjun Li

  • April 30, 2026

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