Efficacy and Safety of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution for Pediatric Wheezing Disorders in China: A Meta-Analysis and Evidence Mapping - Takeaways - DentalSpire

Efficacy and Safety of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution for Pediatric Wheezing Disorders in China: A Meta-Analysis and Evidence Mapping

  • By

  • Yongsheng Guo

  • Run Guo

  • Yingxue Zou

  • Bing Huang

  • Jiao Li

  • Mei Yu

  • Jia Zhai

  • Shiyin Mu

  • Yingying An

  • Weiwei Gao

  • April 22, 2026

  • 0 min

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  • 1

    Ambroxol hydrochloride and clenbuterol hydrochloride oral solution (AHCHOS) significantly improves symptom resolution in pediatric wheezing disorders.

  • 2

    Meta-analysis showed AHCHOS reduced coughing, wheezing, and hospital stay duration compared to conventional treatments.

  • 3

    The study included 227 randomized controlled trials, with 14 qualifying for meta-analysis, primarily from eastern China.

  • 4

    AHCHOS did not increase the risk of adverse events compared to conventional treatments, though safety reporting was inconsistent.

  • 5

    Findings may have limited generalizability due to all studies being conducted in China, necessitating further research.

Original Source(s)

Efficacy and Safety of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution for Pediatric Wheezing Disorders in China: A Meta-Analysis and Evidence Mapping

  • by Yongsheng Guo, Run Guo, Yingxue Zou, Bing Huang, Jiao Li, Mei Yu, Jia Zhai, Shiyin Mu, Yingying An, Weiwei Gao

  • April 22, 2026

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