Investigation of NETO2 Expression, Its Prognostic Significance, and Impact on the Immune Microenvironment in Oral Squamous Cell Carcinoma - Takeaways - DentalSpire

Investigation of NETO2 Expression, Its Prognostic Significance, and Impact on the Immune Microenvironment in Oral Squamous Cell Carcinoma

  • By

  • Jinhang Wang

  • Zifeng Cui

  • Kaicheng Yang

  • Yalin Zhang

  • Shixiong Peng

  • November 5, 2025

  • 0 min

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  • 1

    NETO2 is significantly upregulated in oral squamous cell carcinoma (OSCC) and correlates with tumor progression and patient survival.

  • 2

    The study utilized RNA-seq data from 330 OSCC samples and 32 normal samples to analyze NETO2 expression and its prognostic significance.

  • 3

    Cox regression analysis was performed to assess the impact of NETO2 expression on survival outcomes, leading to the development of a nomogram model.

  • 4

    Differential expression analysis identified key pathways associated with NETO2, highlighting its role in the immune microenvironment of OSCC.

  • 5

    The findings suggest that NETO2 could serve as a potential diagnostic biomarker and therapeutic target for improving OSCC prognosis.

Original Source(s)

Investigation of NETO2 Expression, Its Prognostic Significance, and Impact on the Immune Microenvironment in Oral Squamous Cell Carcinoma

  • by Jinhang Wang, Zifeng Cui, Kaicheng Yang, Yalin Zhang, Shixiong Peng

  • November 5, 2025

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