Vascular Medicine Imaging: Navigating the Spectrum of Common and Rare Type IV Hypersensitivity Reactions to Cyanoacrylate - Takeaways - DentalSpire

Vascular Medicine Imaging: Navigating the Spectrum of Common and Rare Type IV Hypersensitivity Reactions to Cyanoacrylate

  • By

  • Trevin Eggleston

  • Meghana Malempati

  • Nehali Patel

  • Cole Taube

  • Oscar Moreno

  • Andrea Obi

  • February 25, 2026

  • 0 min

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  • 1

    A 67-year-old woman developed delayed complications after cyanoacrylate closure of the left great saphenous vein, including phlebitis and draining wounds.

  • 2

    Duplex ultrasound revealed cyanoacrylate presence intravascularly and in an extravascular mass, indicating local perforation and extravasation.

  • 3

    Histological examination showed a predominance of lymphocytes and collagen deposition, consistent with a type IV hypersensitivity reaction.

  • 4

    The case highlights that cyanoacrylate extravasation can lead to rare encapsulated mass formation related to type IV hypersensitivity.

  • 5

    Surgical therapy was curative, but additional immunomodulatory agents could potentially reduce the need for surgery in similar cases.

Original Source(s)

Vascular Medicine Imaging: Navigating the Spectrum of Common and Rare Type IV Hypersensitivity Reactions to Cyanoacrylate

  • by Trevin Eggleston, Meghana Malempati, Nehali Patel, Cole Taube, Oscar Moreno, Andrea Obi

  • February 25, 2026

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